| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | USP28 | Ser714 | ESSTNSSsQDYSTSQ | phosphorylation down-regulates activity | 31938050 | SIGNOR-275853 |
| ATR | USP28 | Ser714 | ESSTNSSsQDYSTSQ | phosphorylation up-regulates activity | 31938050 | SIGNOR-275851 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | USP28 PSer714 | phosphorylation down-regulates ⊣ | USP28 | 31938050 | SIGNOR-275853 |
| ATR | phosphorylation up-regulates → | USP28 PSer714 | phosphorylation up-regulates → | USP28 | 31938050 | SIGNOR-275851 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation → down-regulates activity | USP28 | SIGNOR-275853 |
| ATR | phosphorylation → up-regulates activity | USP28 | SIGNOR-275851 |