| Name | UHRF1 |
| ID | Q96T88 |
| Role | substrate |
| Enzymatic Domains |
Ubiquitin-like 1-78 PROSITE-ProRule
YDG 419-582 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | UHRF1 | Ser95 | SELSDTDsGCCLGQS | phosphorylation up-regulates | 23297342 | SIGNOR-200349 |
| CyclinB/CDK1 | UHRF1 | Ser639 | QQEGGFAsPRTGKGK | phosphorylation down-regulates quantity by destabilization | 22411829 | SIGNOR-276408 |
| CDK2 | UHRF1 | Ser675 | KTKVEPYsLTAQQSS | phosphorylation down-regulates quantity by destabilization | 26727879 | SIGNOR-277192 |
| PIM1 | UHRF1 | Ser311 | S-->R | phosphorylation down-regulates quantity by destabilization | 28394343 | SIGNOR-277349 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK1D | phosphorylation up-regulates → | UHRF1 PSer95 | phosphorylation up-regulates → | UHRF1 | 23297342 | SIGNOR-200349 |
| CyclinB/CDK1 | phosphorylation up-regulates → | UHRF1 PSer639 | phosphorylation down-regulates ⊣ | UHRF1 | 22411829 | SIGNOR-276408 |
| CDK2 | phosphorylation up-regulates → | UHRF1 PSer675 | phosphorylation down-regulates ⊣ | UHRF1 | 26727879 | SIGNOR-277192 |
| PIM1 | phosphorylation up-regulates → | UHRF1 PSer311 | phosphorylation down-regulates ⊣ | UHRF1 | 28394343 | SIGNOR-277349 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK1D | phosphorylation → up-regulates | UHRF1 | SIGNOR-200349 |
| CyclinB/CDK1 | phosphorylation down-regulates quantity by destabilization | UHRF1 | SIGNOR-276408 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | UHRF1 | SIGNOR-277192 |
| PIM1 | phosphorylation down-regulates quantity by destabilization | UHRF1 | SIGNOR-277349 |