| Name | SCN2A |
| ID | Q99250 |
| Role | substrate |
| Enzymatic Domains |
IQ 1905-1934 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A3 | SCN2A | Ser1112 | VPIAVGEsDFENLNT | phosphorylation up-regulates activity | 19064667 | SIGNOR-275751 |
| CSNK2A1 | SCN2A | Ser1124 | LNTEEFSsESDMEES | phosphorylation up-regulates activity | 19064667 | SIGNOR-275757 |
| CSNK2A3 | SCN2A | Ser1126 | TEEFSSEsDMEESKE | phosphorylation up-regulates activity | 19064667 | SIGNOR-275759 |
| CSNK2A2 | SCN2A | Ser1124 | LNTEEFSsESDMEES | phosphorylation up-regulates activity | 19064667 | SIGNOR-275758 |
| CSNK2A1 | SCN2A | Ser1126 | TEEFSSEsDMEESKE | phosphorylation up-regulates activity | 19064667 | SIGNOR-275761 |
| PKC | SCN2A | – | phosphorylation down-regulates activity | 32599005 | SIGNOR-275750 | |
| CSNK2B | SCN2A | Ser1126 | TEEFSSEsDMEESKE | phosphorylation up-regulates activity | 19064667 | SIGNOR-275760 |
| CSNK2A3 | SCN2A | Ser1124 | LNTEEFSsESDMEES | phosphorylation up-regulates activity | 19064667 | SIGNOR-275755 |
| CSNK2B | SCN2A | Ser1124 | LNTEEFSsESDMEES | phosphorylation up-regulates activity | 19064667 | SIGNOR-275756 |
| CSNK2A2 | SCN2A | Ser1126 | TEEFSSEsDMEESKE | phosphorylation up-regulates activity | 19064667 | SIGNOR-275762 |
| GSK3B | SCN2A | Thr1966 | TPEKTDMtPSTTSPP | phosphorylation down-regulates activity | 32599005 | SIGNOR-275748 |
| CSNK2A1 | SCN2A | Ser1112 | VPIAVGEsDFENLNT | phosphorylation up-regulates activity | 19064667 | SIGNOR-275753 |
| CSNK2A2 | SCN2A | Ser1112 | VPIAVGEsDFENLNT | phosphorylation up-regulates activity | 19064667 | SIGNOR-275754 |
| PKA | SCN2A | – | phosphorylation down-regulates activity | 32599005 | SIGNOR-275749 | |
| CSNK2B | SCN2A | Ser1112 | VPIAVGEsDFENLNT | phosphorylation up-regulates activity | 19064667 | SIGNOR-275752 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A3 | phosphorylation up-regulates → | SCN2A PSer1112 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275751 |
| CSNK2A1 | phosphorylation up-regulates → | SCN2A PSer1124 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275757 |
| CSNK2A3 | phosphorylation up-regulates → | SCN2A PSer1126 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275759 |
| CSNK2A2 | phosphorylation up-regulates → | SCN2A PSer1124 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275758 |
| CSNK2A1 | phosphorylation up-regulates → | SCN2A PSer1126 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275761 |
| CSNK2B | phosphorylation up-regulates → | SCN2A PSer1126 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275760 |
| CSNK2A3 | phosphorylation up-regulates → | SCN2A PSer1124 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275755 |
| CSNK2B | phosphorylation up-regulates → | SCN2A PSer1124 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275756 |
| CSNK2A2 | phosphorylation up-regulates → | SCN2A PSer1126 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275762 |
| GSK3B | phosphorylation up-regulates → | SCN2A PThr1966 | phosphorylation down-regulates ⊣ | SCN2A | 32599005 | SIGNOR-275748 |
| CSNK2A1 | phosphorylation up-regulates → | SCN2A PSer1112 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275753 |
| CSNK2A2 | phosphorylation up-regulates → | SCN2A PSer1112 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275754 |
| CSNK2B | phosphorylation up-regulates → | SCN2A PSer1112 | phosphorylation up-regulates → | SCN2A | 19064667 | SIGNOR-275752 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A3 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275751 |
| CSNK2A1 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275757 |
| CSNK2A3 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275759 |
| CSNK2A2 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275758 |
| CSNK2A1 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275761 |
| PKC | phosphorylation → down-regulates activity | SCN2A | SIGNOR-275750 |
| CSNK2B | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275760 |
| CSNK2A3 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275755 |
| CSNK2B | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275756 |
| CSNK2A2 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275762 |
| GSK3B | phosphorylation → down-regulates activity | SCN2A | SIGNOR-275748 |
| CSNK2A1 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275753 |
| CSNK2A2 | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275754 |
| PKA | phosphorylation → down-regulates activity | SCN2A | SIGNOR-275749 |
| CSNK2B | phosphorylation → up-regulates activity | SCN2A | SIGNOR-275752 |