| Name | MAP3K14 |
| ID | Q99558 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 400-655 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K14 | IKBKB | – | phosphorylation up-regulates | 9520446 | SIGNOR-55949 | |
| MAP3K14 | CHUK | – | phosphorylation up-regulates activity | 20651737 | SIGNOR-167060 | |
| MAP3K14 | CHUK | Ser176 | AKDVDQGsLCTSFVG | phosphorylation up-regulates activity | 9520446 | SIGNOR-55942 |
| MAP3K14 | CHUK | Ser180 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 9520446 | SIGNOR-55946 |
| MAP3K14 | G6PD | Ser40 | IFIIMGAsGDLAKKK | phosphorylation up-regulates activity | 33398181 | SIGNOR-277545 |
| MAP3K14 | SLC9A1 | – | phosphorylation up-regulates activity | 11369779 | SIGNOR-279632 | |
| MAP3K14 | STAT3 | Ser727 | NTIDLPMsPRTLDSL | phosphorylation up-regulates activity | 17543278 | SIGNOR-279340 |
| MAP3K14 | STAT3 | Tyr705 | DPGSAAPyLKTKFIC | phosphorylation up-regulates activity | 17543278 | SIGNOR-279341 |
| MAP3K14 | MMP14 | – | phosphorylation up-regulates activity | 27270613 | SIGNOR-279631 | |
| MAP3K14 | NFKB2 | Ser866 | TAEVKEDsAYGSQSV | phosphorylation up-regulates activity | 11239468 | SIGNOR-105553 |
| MAP3K14 | NFKB2 | Ser870 | KEDSAYGsQSVEQEA | phosphorylation up-regulates activity | 11239468 | SIGNOR-105557 |
| MAP3K14 | MAP3K14 | – | phosphorylation up-regulates activity | 20651737 | SIGNOR-167063 | |
| MAP3K14 | IKK-complex | – | phosphorylation up-regulates | 9520446 | SIGNOR-217433 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K14 | phosphorylation up-regulates → | CHUK PSer176 | phosphorylation up-regulates → | CHUK | 9520446 | SIGNOR-55942 |
| MAP3K14 | phosphorylation up-regulates → | CHUK PSer180 | phosphorylation up-regulates → | CHUK | 9520446 | SIGNOR-55946 |
| MAP3K14 | phosphorylation up-regulates → | G6PD PSer40 | phosphorylation up-regulates → | G6PD | 33398181 | SIGNOR-277545 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PSer727 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279340 |
| MAP3K14 | phosphorylation up-regulates → | STAT3 PTyr705 | phosphorylation up-regulates → | STAT3 | 17543278 | SIGNOR-279341 |
| MAP3K14 | phosphorylation up-regulates → | NFKB2 PSer866 | phosphorylation up-regulates → | NFKB2 | 11239468 | SIGNOR-105553 |
| MAP3K14 | phosphorylation up-regulates → | NFKB2 PSer870 | phosphorylation up-regulates → | NFKB2 | 11239468 | SIGNOR-105557 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K14 | phosphorylation → up-regulates | IKBKB | SIGNOR-55949 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-167060 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-55942 |
| MAP3K14 | phosphorylation → up-regulates activity | CHUK | SIGNOR-55946 |
| MAP3K14 | phosphorylation → up-regulates activity | G6PD | SIGNOR-277545 |
| MAP3K14 | phosphorylation → up-regulates activity | SLC9A1 | SIGNOR-279632 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279340 |
| MAP3K14 | phosphorylation → up-regulates activity | STAT3 | SIGNOR-279341 |
| MAP3K14 | phosphorylation → up-regulates activity | MMP14 | SIGNOR-279631 |
| MAP3K14 | phosphorylation → up-regulates activity | NFKB2 | SIGNOR-105553 |
| MAP3K14 | phosphorylation → up-regulates activity | NFKB2 | SIGNOR-105557 |
| MAP3K14 | phosphorylation → up-regulates activity | MAP3K14 | SIGNOR-167063 |
| MAP3K14 | phosphorylation → up-regulates | IKK-complex | SIGNOR-217433 |