Entity Details

Name MAP3K14
ID Q99558
Role substrate
Enzymatic Domains
Protein kinase 400-655
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
CHUKMAP3K14Thr559TGDYIPGtETHMAPEphosphorylation
down-regulates quantity by destabilization		20501937SIGNOR-165622
MAP3K7MAP3K14–phosphorylation
up-regulates activity		10094049SIGNOR-262833
MAP3K14MAP3K14–phosphorylation
up-regulates activity		20651737SIGNOR-167063
TBK1MAP3K14–phosphorylation
down-regulates quantity by destabilization		23023393SIGNOR-279767
MAP3K8MAP3K14Thr559TGDYIPGtETHMAPEphosphorylation
up-regulates activity		9742107SIGNOR-249387
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
CHUKphosphorylation
up-regulates
→
MAP3K14
PThr559		phosphorylation
down-regulates
⊣		MAP3K1420501937SIGNOR-165622
MAP3K8phosphorylation
up-regulates
→
MAP3K14
PThr559		phosphorylation
up-regulates
→		MAP3K149742107SIGNOR-249387
Regulator Mechanism/Effect Target SIGNOR-ID
CHUKphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAP3K14SIGNOR-165622
MAP3K7phosphorylation
→
up-regulates activity 		MAP3K14SIGNOR-262833
MAP3K14phosphorylation
→
up-regulates activity 		MAP3K14SIGNOR-167063
TBK1phosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		MAP3K14SIGNOR-279767
MAP3K8phosphorylation
→
up-regulates activity 		MAP3K14SIGNOR-249387