| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | CDX2 | Ser287 | EPLSPVSsLQASVPG | phosphorylation unknown | 16027724 | SIGNOR-251228 |
| MAPK14 | CDX2 | Ser291 | PVSSLQAsVPGSVPG | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250094 |
| MAPK14 | CDX2 | Ser287 | EPLSPVSsLQASVPG | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250093 |
| CDK2 | CDX2 | Ser295 | LQASVPGsVPGVLGP | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250730 |
| CDK2 | CDX2 | Ser291 | PVSSLQAsVPGSVPG | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250729 |
| CDK2 | CDX2 | Ser287 | EPLSPVSsLQASVPG | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250728 |
| GSK3B | CDX2 | Ser295 | LQASVPGsVPGVLGP | phosphorylation unknown | 16027724 | SIGNOR-251230 |
| MAPK14 | CDX2 | Ser283 | RSVPEPLsPVSSLQA | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250092 |
| CDK2 | CDX2 | Ser283 | RSVPEPLsPVSSLQA | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-138825 |
| GSK3B | CDX2 | Ser283 | RSVPEPLsPVSSLQA | phosphorylation unknown | 16027724 | SIGNOR-251227 |
| GSK3B | CDX2 | Ser291 | PVSSLQAsVPGSVPG | phosphorylation unknown | 16027724 | SIGNOR-251229 |
| MAPK14 | CDX2 | Ser295 | LQASVPGsVPGVLGP | phosphorylation down-regulates quantity by destabilization | 16027724 | SIGNOR-250095 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| GSK3B | phosphorylation up-regulates → | CDX2 PSer287 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-251228 |
| MAPK14 | phosphorylation up-regulates → | CDX2 PSer291 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250094 |
| MAPK14 | phosphorylation up-regulates → | CDX2 PSer287 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250093 |
| CDK2 | phosphorylation up-regulates → | CDX2 PSer295 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250730 |
| CDK2 | phosphorylation up-regulates → | CDX2 PSer291 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250729 |
| CDK2 | phosphorylation up-regulates → | CDX2 PSer287 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250728 |
| GSK3B | phosphorylation up-regulates → | CDX2 PSer295 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-251230 |
| MAPK14 | phosphorylation up-regulates → | CDX2 PSer283 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250092 |
| CDK2 | phosphorylation up-regulates → | CDX2 PSer283 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-138825 |
| GSK3B | phosphorylation up-regulates → | CDX2 PSer283 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-251227 |
| GSK3B | phosphorylation up-regulates → | CDX2 PSer291 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-251229 |
| MAPK14 | phosphorylation up-regulates → | CDX2 PSer295 | phosphorylation down-regulates ⊣ | CDX2 | 16027724 | SIGNOR-250095 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| GSK3B | phosphorylation → unknown | CDX2 | SIGNOR-251228 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250094 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250093 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250730 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250729 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250728 |
| GSK3B | phosphorylation → unknown | CDX2 | SIGNOR-251230 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250092 |
| CDK2 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-138825 |
| GSK3B | phosphorylation → unknown | CDX2 | SIGNOR-251227 |
| GSK3B | phosphorylation → unknown | CDX2 | SIGNOR-251229 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | CDX2 | SIGNOR-250095 |
