| Name | DOK1 |
| ID | Q99704 |
| Role | substrate |
| Enzymatic Domains |
PH 4-119
IRS-type PTB 151-259 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | DOK1 | Ser439 | EPGTATGsGIKSHNS | phosphorylation up-regulates | 15574499 | SIGNOR-131447 |
| PTK6 | DOK1 | Tyr362 | DPKEDPIyDEPEGLA | phosphorylation down-regulates activity | 24523872 | SIGNOR-278301 |
| IKBKB | DOK1 | Ser443 | ATGSGIKsHNSALYS | phosphorylation up-regulates | 15574499 | SIGNOR-131451 |
| IKBKB | DOK1 | Ser450 | SHNSALYsQVQKSGA | phosphorylation up-regulates | 15574499 | SIGNOR-131556 |
| LCK | DOK1 | – | phosphorylation up-regulates activity | 10799545 | SIGNOR-251373 | |
| INSR | DOK1 | Tyr398 | ARVKEEGyELPYNPA | phosphorylation up-regulates activity | 11551902 | SIGNOR-251308 |
| IKBKB | DOK1 | Ser446 | SGIKSHNsALYSQVQ | phosphorylation up-regulates | 15574499 | SIGNOR-131455 |
| INSR | DOK1 | Tyr362 | DPKEDPIyDEPEGLA | phosphorylation up-regulates activity | 11551902 | SIGNOR-251307 |
| SRMS | DOK1 | – | phosphorylation unknown | 23822091 | SIGNOR-264569 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| IKBKB | phosphorylation up-regulates → | DOK1 PSer439 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131447 |
| PTK6 | phosphorylation up-regulates → | DOK1 PTyr362 | phosphorylation down-regulates ⊣ | DOK1 | 24523872 | SIGNOR-278301 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer443 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131451 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer450 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131556 |
| INSR | phosphorylation up-regulates → | DOK1 PTyr398 | phosphorylation up-regulates → | DOK1 | 11551902 | SIGNOR-251308 |
| IKBKB | phosphorylation up-regulates → | DOK1 PSer446 | phosphorylation up-regulates → | DOK1 | 15574499 | SIGNOR-131455 |
| INSR | phosphorylation up-regulates → | DOK1 PTyr362 | phosphorylation up-regulates → | DOK1 | 11551902 | SIGNOR-251307 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131447 |
| PTK6 | phosphorylation → down-regulates activity | DOK1 | SIGNOR-278301 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131451 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131556 |
| LCK | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251373 |
| INSR | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251308 |
| IKBKB | phosphorylation → up-regulates | DOK1 | SIGNOR-131455 |
| INSR | phosphorylation → up-regulates activity | DOK1 | SIGNOR-251307 |
| SRMS | phosphorylation → unknown | DOK1 | SIGNOR-264569 |