| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | RBBP8 | Ser664 | IDPGADLsQYKMDVT | phosphorylation down-regulates | 10910365 | SIGNOR-79872 |
| PKM | RBBP8 | Thr126 | ELMNERNtLQEENKK | phosphorylation up-regulates activity | 30297868 | SIGNOR-277413 |
| ATR | RBBP8 | Thr859 | WEVGFPStQTCMERG | phosphorylation up-regulates | 23273981 | SIGNOR-200245 |
| ATM | RBBP8 | Ser745 | SCLADSFsQAADEEE | phosphorylation down-regulates | 10910365 | SIGNOR-79876 |
| CyclinA2/CDK2 | RBBP8 | Ser327 | ELPTRVSsPVFGATS | phosphorylation up-regulates activity | 15485915 | SIGNOR-263227 |
| CDK2 | RBBP8 | Thr847 | FRYIPPNtPENFWEV | phosphorylation up-regulates | 19202191 | SIGNOR-183840 |
| PLK1 | RBBP8 | – | phosphorylation up-regulates activity | 30202980 | SIGNOR-279253 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | RBBP8 PSer664 | phosphorylation down-regulates ⊣ | RBBP8 | 10910365 | SIGNOR-79872 |
| PKM | phosphorylation up-regulates → | RBBP8 PThr126 | phosphorylation up-regulates → | RBBP8 | 30297868 | SIGNOR-277413 |
| ATR | phosphorylation up-regulates → | RBBP8 PThr859 | phosphorylation up-regulates → | RBBP8 | 23273981 | SIGNOR-200245 |
| ATM | phosphorylation up-regulates → | RBBP8 PSer745 | phosphorylation down-regulates ⊣ | RBBP8 | 10910365 | SIGNOR-79876 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | RBBP8 PSer327 | phosphorylation up-regulates → | RBBP8 | 15485915 | SIGNOR-263227 |
| CDK2 | phosphorylation up-regulates → | RBBP8 PThr847 | phosphorylation up-regulates → | RBBP8 | 19202191 | SIGNOR-183840 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation![]() down-regulates | RBBP8 | SIGNOR-79872 |
| PKM | phosphorylation → up-regulates activity | RBBP8 | SIGNOR-277413 |
| ATR | phosphorylation → up-regulates | RBBP8 | SIGNOR-200245 |
| ATM | phosphorylation![]() down-regulates | RBBP8 | SIGNOR-79876 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | RBBP8 | SIGNOR-263227 |
| CDK2 | phosphorylation → up-regulates | RBBP8 | SIGNOR-183840 |
| PLK1 | phosphorylation → up-regulates activity | RBBP8 | SIGNOR-279253 |