| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | CDC6 | Ser106 | DNQLTIKsPSKRELA | phosphorylation up-regulates | 10339564 | SIGNOR-67540 |
| CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 10339564 | SIGNOR-67548 |
| CyclinA2/CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 9889196 | SIGNOR-217332 |
| CyclinA2/CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 10339564 | SIGNOR-217280 |
| CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 10339564 | SIGNOR-67544 |
| CyclinA2/CDK2 | CDC6 | Ser106 | DNQLTIKsPSKRELA | phosphorylation up-regulates | 10339564 | SIGNOR-217272 |
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 10339564 | SIGNOR-217276 |
| CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 9889196 | SIGNOR-63891 |
| CDK2 | CDC6 | Ser74 | TPHLPPCsPPKQGKK | phosphorylation down-regulates activity | 9889196 | SIGNOR-63895 |
| PLK1 | CDC6 | Thr37 | SDAKLEPtNVQTVTC | phosphorylation up-regulates | 21041660 | SIGNOR-169184 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | CDC6 PSer106 | phosphorylation up-regulates → | CDC6 | 10339564 | SIGNOR-67540 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-67548 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-217332 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-217280 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-67544 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer106 | phosphorylation up-regulates → | CDC6 | 10339564 | SIGNOR-217272 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-217276 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-63891 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer74 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-63895 |
| PLK1 | phosphorylation up-regulates → | CDC6 PThr37 | phosphorylation up-regulates → | CDC6 | 21041660 | SIGNOR-169184 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation → up-regulates | CDC6 | SIGNOR-67540 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-67548 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217332 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217280 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-67544 |
| CyclinA2/CDK2 | phosphorylation → up-regulates | CDC6 | SIGNOR-217272 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217276 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-63891 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-63895 |
| PLK1 | phosphorylation → up-regulates | CDC6 | SIGNOR-169184 |
