Entity Details

Name	CDC6_Ser54
ID	Q99741
Role	residue
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Data Summary

PTM Format

SIGNOR Summary

Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
CyclinA2/CDK2	CDC6	Ser54 View in OncoXplorer	RVKALPLsPRKRLGD	phosphorylation down-regulates activity	9889196	SIGNOR-217328
CyclinA2/CDK2	CDC6	Ser54 View in OncoXplorer	RVKALPLsPRKRLGD	phosphorylation down-regulates activity	10339564	SIGNOR-217276
CDK2	CDC6	Ser54 View in OncoXplorer	RVKALPLsPRKRLGD	phosphorylation down-regulates activity	10339564	SIGNOR-67544
CDK2	CDC6	Ser54 View in OncoXplorer	RVKALPLsPRKRLGD	phosphorylation down-regulates activity	9889196	SIGNOR-63891

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
CyclinA2/CDK2	phosphorylation up-regulates →	CDC6 PSer54	phosphorylation down-regulates ⊣	CDC6	9889196	SIGNOR-217328
CyclinA2/CDK2	phosphorylation up-regulates →	CDC6 PSer54	phosphorylation down-regulates ⊣	CDC6	10339564	SIGNOR-217276
CDK2	phosphorylation up-regulates →	CDC6 PSer54	phosphorylation down-regulates ⊣	CDC6	10339564	SIGNOR-67544
CDK2	phosphorylation up-regulates →	CDC6 PSer54	phosphorylation down-regulates ⊣	CDC6	9889196	SIGNOR-63891

Regulator	Mechanism/Effect	Target	SIGNOR-ID
CyclinA2/CDK2	phosphorylation → down-regulates activity	CDC6	SIGNOR-217328
CyclinA2/CDK2	phosphorylation → down-regulates activity	CDC6	SIGNOR-217276
CDK2	phosphorylation → down-regulates activity	CDC6	SIGNOR-67544
CDK2	phosphorylation → down-regulates activity	CDC6	SIGNOR-63891