| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 10339564 | SIGNOR-217276 |
| CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 9889196 | SIGNOR-63891 |
| CDK2 | CDC6 | Ser54 | RVKALPLsPRKRLGD | phosphorylation down-regulates activity | 10339564 | SIGNOR-67544 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-217276 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 9889196 | SIGNOR-63891 |
| CDK2 | phosphorylation up-regulates → | CDC6 PSer54 | phosphorylation down-regulates ⊣ | CDC6 | 10339564 | SIGNOR-67544 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217328 |
| CyclinA2/CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-217276 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-63891 |
| CDK2 | phosphorylation → down-regulates activity | CDC6 | SIGNOR-67544 |