| Name | MAP3K3 |
| ID | Q99759 |
| Role | kinase |
| Enzymatic Domains |
PB1 44-123 PROSITE-ProRule
Protein kinase 362-622 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | IKBKB | Ser177 | AKELDQGsLCTSFVG | phosphorylation up-regulates activity | 14636585 | SIGNOR-279467 |
| MAP3K3 | IKBKB | Ser181 | DQGSLCTsFVGTLQY | phosphorylation up-regulates activity | 14636585 | SIGNOR-279468 |
| MAP3K3 | MAP2K3 | Ser218 | ISGYLVDsVAKTMDA | phosphorylation up-regulates activity | 9162092 | SIGNOR-48625 |
| MAP3K3 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 12809556 | SIGNOR-102294 |
| MAP3K3 | RCAN1 | Ser167 | FLISPPAsPPVGWKQ | phosphorylation up-regulates | 16126726 | SIGNOR-138945 |
| MAP3K3 | MAP2K5 | – | phosphorylation up-regulates | 12912994 | SIGNOR-104637 | |
| MAP3K3 | SQSTM1 | Ser272 | RSRLTPVsPESSSTE | phosphorylation up-regulates activity | 26279575 | SIGNOR-279533 |
| MAP3K3 | SQSTM1 | Thr269 | GGKRSRLtPVSPESS | phosphorylation up-regulates activity | 26279575 | SIGNOR-279532 |
| MAP3K3 | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | phosphorylation up-regulates | 16407301 | SIGNOR-143647 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer177 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279467 |
| MAP3K3 | phosphorylation up-regulates → | IKBKB PSer181 | phosphorylation up-regulates → | IKBKB | 14636585 | SIGNOR-279468 |
| MAP3K3 | phosphorylation up-regulates → | MAP2K3 PSer218 | phosphorylation up-regulates → | MAP2K3 | 9162092 | SIGNOR-48625 |
| MAP3K3 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 12809556 | SIGNOR-102294 |
| MAP3K3 | phosphorylation up-regulates → | RCAN1 PSer167 | phosphorylation up-regulates → | RCAN1 | 16126726 | SIGNOR-138945 |
| MAP3K3 | phosphorylation up-regulates → | SQSTM1 PSer272 | phosphorylation up-regulates → | SQSTM1 | 26279575 | SIGNOR-279533 |
| MAP3K3 | phosphorylation up-regulates → | SQSTM1 PThr269 | phosphorylation up-regulates → | SQSTM1 | 26279575 | SIGNOR-279532 |
| MAP3K3 | phosphorylation up-regulates → | MAP3K3 PSer526 | phosphorylation up-regulates → | MAP3K3 | 16407301 | SIGNOR-143647 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279467 |
| MAP3K3 | phosphorylation → up-regulates activity | IKBKB | SIGNOR-279468 |
| MAP3K3 | phosphorylation → up-regulates activity | MAP2K3 | SIGNOR-48625 |
| MAP3K3 | phosphorylation → up-regulates | RCAN1 | SIGNOR-102294 |
| MAP3K3 | phosphorylation → up-regulates | RCAN1 | SIGNOR-138945 |
| MAP3K3 | phosphorylation → up-regulates | MAP2K5 | SIGNOR-104637 |
| MAP3K3 | phosphorylation → up-regulates activity | SQSTM1 | SIGNOR-279533 |
| MAP3K3 | phosphorylation → up-regulates activity | SQSTM1 | SIGNOR-279532 |
| MAP3K3 | phosphorylation → up-regulates | MAP3K3 | SIGNOR-143647 |