| Name | MAP3K3 |
| ID | Q99759 |
| Role | substrate |
| Enzymatic Domains |
PB1 44-123 PROSITE-ProRule
Protein kinase 362-622 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | MAP3K3 | Ser166 | EPRSRHLsVSSQNPG | phosphorylation down-regulates activity | 12761204 | SIGNOR-101211 |
| MAP3K3 | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | phosphorylation up-regulates | 16407301 | SIGNOR-143647 |
| SGK1 | MAP3K3 | Ser337 | DPRGRLRsADSENAL | phosphorylation down-regulates activity | 12761205 | SIGNOR-101216 |
| PPP2CA | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | dephosphorylation down-regulates | 20448038 | SIGNOR-165233 |
| PPP2CA | MAP3K3 | Thr516 | GASKRLQtICMSGTG | dephosphorylation down-regulates | 20448038 | SIGNOR-165237 |
| SGK1 | MAP3K3 | Ser337 | DPRGRLRsADSENAL | phosphorylation down-regulates activity | 12392720 | SIGNOR-250005 |
| PPP2CA | MAP3K3 | Ser520 | RLQTICMsGTGMRSV | dephosphorylation down-regulates | 20448038 | SIGNOR-165229 |
| SGK1 | MAP3K3 | Ser166 | EPRSRHLsVSSQNPG | phosphorylation down-regulates activity | 12392720 | SIGNOR-250004 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer166 | phosphorylation down-regulates ⊣ | MAP3K3 | 12761204 | SIGNOR-101211 |
| MAP3K3 | phosphorylation up-regulates → | MAP3K3 PSer526 | phosphorylation up-regulates → | MAP3K3 | 16407301 | SIGNOR-143647 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer337 | phosphorylation down-regulates ⊣ | MAP3K3 | 12761205 | SIGNOR-101216 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PSer526 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165233 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PThr516 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165237 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer337 | phosphorylation down-regulates ⊣ | MAP3K3 | 12392720 | SIGNOR-250005 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PSer520 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165229 |
| SGK1 | phosphorylation up-regulates → | MAP3K3 PSer166 | phosphorylation down-regulates ⊣ | MAP3K3 | 12392720 | SIGNOR-250004 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-101211 |
| MAP3K3 | phosphorylation → up-regulates | MAP3K3 | SIGNOR-143647 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-101216 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165233 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165237 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-250005 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165229 |
| SGK1 | phosphorylation → down-regulates activity | MAP3K3 | SIGNOR-250004 |