| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | phosphorylation up-regulates | 16407301 | SIGNOR-143647 |
| PPP2CA | MAP3K3 | Ser526 | MSGTGMRsVTGTPYW | dephosphorylation down-regulates | 20448038 | SIGNOR-165233 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAP3K3 | phosphorylation up-regulates → | MAP3K3 PSer526 | phosphorylation up-regulates → | MAP3K3 | 16407301 | SIGNOR-143647 |
| PPP2CA | dephosphorylation down-regulates ⊣ | MAP3K3 PSer526 | dephosphorylation up-regulates → | MAP3K3 | 20448038 | SIGNOR-165233 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAP3K3 | phosphorylation → up-regulates | MAP3K3 | SIGNOR-143647 |
| PPP2CA | dephosphorylation down-regulates | MAP3K3 | SIGNOR-165233 |
