| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | NKX3-1 | Thr166 | KNLKLTEtQVKIWFQ | phosphorylation down-regulates quantity by destabilization | 23890999 | SIGNOR-276500 |
| CSNK2A2 | NKX3-1 | Thr89 | AAPEEAEtLAETEPE | phosphorylation up-regulates | 16581776 | SIGNOR-145501 |
| CSNK2A2 | NKX3-1 | Thr93 | EAETLAEtEPERHLG | phosphorylation up-regulates | 16581776 | SIGNOR-145505 |
| LIMK2 | NKX3-1 | Ser185 | KTKRKQLsSELGDLE | phosphorylation down-regulates activity | 34066036 | SIGNOR-278951 |
| PRKCA | NKX3-1 | Ser48 | RQGGRTSsQRQRDPE | phosphorylation up-regulates | 11980664 | SIGNOR-86723 |
| PTEN | NKX3-1 | Thr179 | FQNRRYKtKRKQLSS | dephosphorylation up-regulates quantity by stabilization | 31213464 | SIGNOR-277026 |
| DYRK1B | NKX3-1 | Ser185 | KTKRKQLsSELGDLE | phosphorylation down-regulates quantity by destabilization | 25777618 | SIGNOR-279610 |
| ATM | NKX3-1 | Thr134 | SRAAFSHtQVIELER | phosphorylation down-regulates quantity by destabilization | 23890999 | SIGNOR-276499 |
| ATM | NKX3-1 | – | phosphorylation down-regulates quantity | 23890999 | SIGNOR-279726 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| ATM | phosphorylation up-regulates → | NKX3-1 PThr166 | phosphorylation down-regulates ⊣ | NKX3-1 | 23890999 | SIGNOR-276500 |
| CSNK2A2 | phosphorylation up-regulates → | NKX3-1 PThr89 | phosphorylation up-regulates → | NKX3-1 | 16581776 | SIGNOR-145501 |
| CSNK2A2 | phosphorylation up-regulates → | NKX3-1 PThr93 | phosphorylation up-regulates → | NKX3-1 | 16581776 | SIGNOR-145505 |
| LIMK2 | phosphorylation up-regulates → | NKX3-1 PSer185 | phosphorylation down-regulates ⊣ | NKX3-1 | 34066036 | SIGNOR-278951 |
| PRKCA | phosphorylation up-regulates → | NKX3-1 PSer48 | phosphorylation up-regulates → | NKX3-1 | 11980664 | SIGNOR-86723 |
| PTEN | dephosphorylation down-regulates ⊣ | NKX3-1 PThr179 | dephosphorylation down-regulates ⊣ | NKX3-1 | 31213464 | SIGNOR-277026 |
| DYRK1B | phosphorylation up-regulates → | NKX3-1 PSer185 | phosphorylation down-regulates ⊣ | NKX3-1 | 25777618 | SIGNOR-279610 |
| ATM | phosphorylation up-regulates → | NKX3-1 PThr134 | phosphorylation down-regulates ⊣ | NKX3-1 | 23890999 | SIGNOR-276499 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| ATM | phosphorylation down-regulates quantity by destabilization | NKX3-1 | SIGNOR-276500 |
| CSNK2A2 | phosphorylation → up-regulates | NKX3-1 | SIGNOR-145501 |
| CSNK2A2 | phosphorylation → up-regulates | NKX3-1 | SIGNOR-145505 |
| LIMK2 | phosphorylation → down-regulates activity | NKX3-1 | SIGNOR-278951 |
| PRKCA | phosphorylation → up-regulates | NKX3-1 | SIGNOR-86723 |
| PTEN | dephosphorylation → up-regulates quantity by stabilization | NKX3-1 | SIGNOR-277026 |
| DYRK1B | phosphorylation down-regulates quantity by destabilization | NKX3-1 | SIGNOR-279610 |
| ATM | phosphorylation down-regulates quantity by destabilization | NKX3-1 | SIGNOR-276499 |
| ATM | phosphorylation → down-regulates quantity | NKX3-1 | SIGNOR-279726 |
