Entity Details

Name EPAS1
ID Q99814
Role substrate
Enzymatic Domains
bHLH 14-67
PROSITE-ProRule
PAS 1 84-154
PROSITE-ProRule
PAS 2 230-300
PROSITE-ProRule
PAC 304-347
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PIM1EPAS1Ser435GKAILPPsQPWATELphosphorylation
up-regulates quantity by stabilization		34211090SIGNOR-277310
MAPK1EPAS1Ser484SSCSTPNsPEDYYTSphosphorylation
up-regulates quantity by stabilization		35191554SIGNOR-277585
MAPK3EPAS1Ser484SSCSTPNsPEDYYTSphosphorylation
up-regulates quantity by stabilization		35191554SIGNOR-277584
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PIM1phosphorylation
up-regulates
→
EPAS1
PSer435		phosphorylation
up-regulates
→		EPAS134211090SIGNOR-277310
MAPK1phosphorylation
up-regulates
→
EPAS1
PSer484		phosphorylation
up-regulates
→		EPAS135191554SIGNOR-277585
MAPK3phosphorylation
up-regulates
→
EPAS1
PSer484		phosphorylation
up-regulates
→		EPAS135191554SIGNOR-277584
Regulator Mechanism/Effect Target SIGNOR-ID
PIM1phosphorylation
→
up-regulates quantity by stabilization 		EPAS1SIGNOR-277310
MAPK1phosphorylation
→
up-regulates quantity by stabilization 		EPAS1SIGNOR-277585
MAPK3phosphorylation
→
up-regulates quantity by stabilization 		EPAS1SIGNOR-277584