Entity Details

Name PTPN18
ID Q99952
Role phosphatase
Enzymatic Domains
Tyrosine-protein phosphatase 26-291
PROSITE-ProRule
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
PTPN18ERBB2Tyr1112DPSPLQRySEDPTVPdephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-262595
PTPN18ERBB2Tyr1196GAVENPEyLTPQGGAdephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-262596
PTPN18ERBB2Tyr1248PTAENPEyLGLDVPVdephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-262597
PTPN18ERBB2–dephosphorylation
down-regulates quantity by destabilization		25081058SIGNOR-277031
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
PTPN18dephosphorylation
down-regulates
⊣
ERBB2
PTyr1112		dephosphorylation
up-regulates
→		ERBB225081058SIGNOR-262595
PTPN18dephosphorylation
down-regulates
⊣
ERBB2
PTyr1196		dephosphorylation
up-regulates
→		ERBB225081058SIGNOR-262596
PTPN18dephosphorylation
down-regulates
⊣
ERBB2
PTyr1248		dephosphorylation
up-regulates
→		ERBB225081058SIGNOR-262597
Regulator Mechanism/Effect Target SIGNOR-ID
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-262595
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-262596
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-262597
PTPN18dephosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		ERBB2SIGNOR-277031