Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
VRK1	BANF1	Ser4	sQKHRDFV	phosphorylation down-regulates	16371512	SIGNOR-143285
VRK1	BANF1	Ser4	sQKHRDFV	phosphorylation down-regulates	16495336	SIGNOR-144783
VRK1	BANF1	Thr2	tTSQKHRD	phosphorylation down-regulates	16495336	SIGNOR-144787
VRK1	BANF1	Thr3	tSQKHRDF	phosphorylation down-regulates	16495336	SIGNOR-144791
VRK1	TP53	Thr18	EPPLSQEtFSDLWKL	phosphorylation up-regulates	10951572	SIGNOR-81222
VRK1	JUN	Ser63	KNSDLLTsPDVGLLK	phosphorylation up-regulates	15378002	SIGNOR-127069
VRK1	JUN	Ser73	VGLLKLAsPELERLI	phosphorylation up-regulates	15378002	SIGNOR-127073
VRK1	ATF2	Ser62	FGPARNDsVIVADQT	phosphorylation up-regulates	15105425	SIGNOR-124330
VRK1	ATF2	Thr73	ADQTPTPtRFLKNCE	phosphorylation up-regulates	15105425	SIGNOR-124334
VRK1	H2AX	Ser140	GKKATQAsQEY	phosphorylation up-regulates activity	25923214	SIGNOR-278370
VRK1	COIL	Ser184	NEEAKRKsPKKKEKC	phosphorylation up-regulates quantity by stabilization	26068304	SIGNOR-279772
VRK1	SOX2	–		phosphorylation up-regulates activity	27334688	SIGNOR-279578
VRK1	H3C1	Ser11	TKQTARKsTGGKAPR	phosphorylation unknown	17938195	SIGNOR-158436
VRK1	TP53BP1	–		phosphorylation up-regulates	22621922	SIGNOR-197625
VRK1	AURKB	–		phosphorylation up-regulates activity	29340707	SIGNOR-280160
VRK1	Histone H3	–		phosphorylation unknown	17938195	SIGNOR-265371

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
VRK1	phosphorylation up-regulates →	BANF1 PSer4	phosphorylation down-regulates ⊣	BANF1	16371512	SIGNOR-143285
VRK1	phosphorylation up-regulates →	BANF1 PSer4	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144783
VRK1	phosphorylation up-regulates →	BANF1 PThr2	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144787
VRK1	phosphorylation up-regulates →	BANF1 PThr3	phosphorylation down-regulates ⊣	BANF1	16495336	SIGNOR-144791
VRK1	phosphorylation up-regulates →	TP53 PThr18	phosphorylation up-regulates →	TP53	10951572	SIGNOR-81222
VRK1	phosphorylation up-regulates →	JUN PSer63	phosphorylation up-regulates →	JUN	15378002	SIGNOR-127069
VRK1	phosphorylation up-regulates →	JUN PSer73	phosphorylation up-regulates →	JUN	15378002	SIGNOR-127073
VRK1	phosphorylation up-regulates →	ATF2 PSer62	phosphorylation up-regulates →	ATF2	15105425	SIGNOR-124330
VRK1	phosphorylation up-regulates →	ATF2 PThr73	phosphorylation up-regulates →	ATF2	15105425	SIGNOR-124334
VRK1	phosphorylation up-regulates →	H2AX PSer140	phosphorylation up-regulates →	H2AX	25923214	SIGNOR-278370
VRK1	phosphorylation up-regulates →	COIL PSer184	phosphorylation up-regulates →	COIL	26068304	SIGNOR-279772
VRK1	phosphorylation up-regulates →	H3C1 PSer11	phosphorylation down-regulates ⊣	H3C1	17938195	SIGNOR-158436

Regulator	Mechanism/Effect	Target	SIGNOR-ID
VRK1	phosphorylation down-regulates	BANF1	SIGNOR-143285
VRK1	phosphorylation down-regulates	BANF1	SIGNOR-144783
VRK1	phosphorylation down-regulates	BANF1	SIGNOR-144787
VRK1	phosphorylation down-regulates	BANF1	SIGNOR-144791
VRK1	phosphorylation → up-regulates	TP53	SIGNOR-81222
VRK1	phosphorylation → up-regulates	JUN	SIGNOR-127069
VRK1	phosphorylation → up-regulates	JUN	SIGNOR-127073
VRK1	phosphorylation → up-regulates	ATF2	SIGNOR-124330
VRK1	phosphorylation → up-regulates	ATF2	SIGNOR-124334
VRK1	phosphorylation → up-regulates activity	H2AX	SIGNOR-278370
VRK1	phosphorylation → up-regulates quantity by stabilization	COIL	SIGNOR-279772
VRK1	phosphorylation → up-regulates activity	SOX2	SIGNOR-279578
VRK1	phosphorylation → unknown	H3C1	SIGNOR-158436
VRK1	phosphorylation → up-regulates	TP53BP1	SIGNOR-197625
VRK1	phosphorylation → up-regulates activity	AURKB	SIGNOR-280160
VRK1	phosphorylation → unknown	Histone H3	SIGNOR-265371