| Name | EIF2AK1 |
| ID | Q9BQI3 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 167-583 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK1 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 11041858 | SIGNOR-83226 |
| EIF2AK1 | EIF2S1 | Ser52 | MILLSELsRRRIRSI | phosphorylation down-regulates | 3352609 | SIGNOR-24543 |
| EIF2AK1 | EIF2S1 | – | phosphorylation down-regulates activity | 24714526 | SIGNOR-251817 | |
| EIF2AK1 | EIF2S1 | Ser49 | IEGMILLsELSRRRI | phosphorylation up-regulates | 10563826 | SIGNOR-72152 |
| EIF2AK1 | EIF2S1 | Ser49 | IEGMILLsELSRRRI | phosphorylation up-regulates | 3352609 | SIGNOR-24539 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 11041858 | SIGNOR-83226 |
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer52 | phosphorylation down-regulates ⊣ | EIF2S1 | 3352609 | SIGNOR-24543 |
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer49 | phosphorylation up-regulates → | EIF2S1 | 10563826 | SIGNOR-72152 |
| EIF2AK1 | phosphorylation up-regulates → | EIF2S1 PSer49 | phosphorylation up-regulates → | EIF2S1 | 3352609 | SIGNOR-24539 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| EIF2AK1 | phosphorylation down-regulates | EIF2S1 | SIGNOR-83226 |
| EIF2AK1 | phosphorylation down-regulates | EIF2S1 | SIGNOR-24543 |
| EIF2AK1 | phosphorylation → down-regulates activity | EIF2S1 | SIGNOR-251817 |
| EIF2AK1 | phosphorylation → up-regulates | EIF2S1 | SIGNOR-72152 |
| EIF2AK1 | phosphorylation → up-regulates | EIF2S1 | SIGNOR-24539 |