Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
NEK2	CEP250	Ser2392	AGLHHSLsHSLLAVA	phosphorylation down-regulates	24695856	SIGNOR-204833
NEK2	CEP250	Ser2394 View in OncoXplorer	LHHSLSHsLLAVAQA	phosphorylation down-regulates	24695856	SIGNOR-204837
SIK2	CEP250	Ser2392	AGLHHSLsHSLLAVA	phosphorylation down-regulates	20708153	SIGNOR-167488
SIK2	CEP250	Ser2394 View in OncoXplorer	LHHSLSHsLLAVAQA	phosphorylation unknown	20708153	SIGNOR-167492

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
NEK2	phosphorylation up-regulates →	CEP250 PSer2392	phosphorylation down-regulates ⊣	CEP250	24695856	SIGNOR-204833
NEK2	phosphorylation up-regulates →	CEP250 PSer2394	phosphorylation down-regulates ⊣	CEP250	24695856	SIGNOR-204837
SIK2	phosphorylation up-regulates →	CEP250 PSer2392	phosphorylation down-regulates ⊣	CEP250	20708153	SIGNOR-167488
SIK2	phosphorylation up-regulates →	CEP250 PSer2394	phosphorylation down-regulates ⊣	CEP250	20708153	SIGNOR-167492

Regulator	Mechanism/Effect	Target	SIGNOR-ID
NEK2	phosphorylation down-regulates	CEP250	SIGNOR-204833
NEK2	phosphorylation down-regulates	CEP250	SIGNOR-204837
SIK2	phosphorylation down-regulates	CEP250	SIGNOR-167488
SIK2	phosphorylation → unknown	CEP250	SIGNOR-167492