| Name | CDK19 |
| ID | Q9BWU1 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 21-335 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK19 | NOTCH1 | Ser2513 | EHPFLTPsPESPDQW | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273136 |
| CDK19 | NOTCH1 | Ser2516 | FLTPSPEsPDQWSSS | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273135 |
| CDK19 | NOTCH1 | Thr2511 | VPEHPFLtPSPESPD | phosphorylation down-regulates quantity by destabilization | 25344755 | SIGNOR-273137 |
| CDK19 | PAK1 | Ser174 | TPAVPPVsEDEDDDD | phosphorylation unknown | 19520772 | SIGNOR-185000 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK19 | phosphorylation up-regulates → | NOTCH1 PSer2513 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273136 |
| CDK19 | phosphorylation up-regulates → | NOTCH1 PSer2516 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273135 |
| CDK19 | phosphorylation up-regulates → | NOTCH1 PThr2511 | phosphorylation down-regulates ⊣ | NOTCH1 | 25344755 | SIGNOR-273137 |
| CDK19 | phosphorylation up-regulates → | PAK1 PSer174 | phosphorylation down-regulates ⊣ | PAK1 | 19520772 | SIGNOR-185000 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK19 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273136 |
| CDK19 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273135 |
| CDK19 | phosphorylation down-regulates quantity by destabilization | NOTCH1 | SIGNOR-273137 |
| CDK19 | phosphorylation → unknown | PAK1 | SIGNOR-185000 |