Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
MAP4K1	CARD11	Ser559 View in OncoXplorer	QPPRSRSsIMSITAE	phosphorylation up-regulates activity	19706536	SIGNOR-276258
MAP4K1	CARD11	Ser558	MQPPRSRsSIMSITA	phosphorylation up-regulates activity	19706536	SIGNOR-276257
AKT1	CARD11	Ser558	MQPPRSRsSIMSITA	phosphorylation up-regulates activity	24548923	SIGNOR-276254
PRKCQ	CARD11	Ser893	SPRLSRAsFLFGQLL	phosphorylation down-regulates activity	35230873	SIGNOR-276298
PPP2CA	CARD11	Ser644 View in OncoXplorer	NLMFRKFsLERPFRP	dephosphorylation down-regulates activity	21157432	SIGNOR-248650
AKT1	CARD11	Ser644 View in OncoXplorer	NLMFRKFsLERPFRP	phosphorylation up-regulates activity	24548923	SIGNOR-276255
AKT1	CARD11	Ser644 View in OncoXplorer	NLMFRKFsLERPFRP	phosphorylation up-regulates activity	24548923	SIGNOR-276621
PPP2CB	CARD11	Ser644 View in OncoXplorer	NLMFRKFsLERPFRP	dephosphorylation down-regulates activity	21157432	SIGNOR-248607
MAP4K1	CARD11	Ser556 View in OncoXplorer	TKMQPPRsRSSIMSI	phosphorylation up-regulates activity	19706536	SIGNOR-276259
AKT1	CARD11	Ser652	LERPFRPsVTSVGHV	phosphorylation up-regulates activity	24548923	SIGNOR-276620
PDPK1	CARD11	–		phosphorylation up-regulates	15802604	SIGNOR-134866
AKT1	CARD11	Ser652	LERPFRPsVTSVGHV	phosphorylation up-regulates activity	24548923	SIGNOR-276256
PRKCQ	CARD11	Ser644 View in OncoXplorer	NLMFRKFsLERPFRP	phosphorylation up-regulates activity	21157432	SIGNOR-249193

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
MAP4K1	phosphorylation up-regulates →	CARD11 PSer559	phosphorylation up-regulates →	CARD11	19706536	SIGNOR-276258
MAP4K1	phosphorylation up-regulates →	CARD11 PSer558	phosphorylation up-regulates →	CARD11	19706536	SIGNOR-276257
AKT1	phosphorylation up-regulates →	CARD11 PSer558	phosphorylation up-regulates →	CARD11	24548923	SIGNOR-276254
PRKCQ	phosphorylation up-regulates →	CARD11 PSer893	phosphorylation down-regulates ⊣	CARD11	35230873	SIGNOR-276298
PPP2CA	dephosphorylation down-regulates ⊣	CARD11 PSer644	dephosphorylation up-regulates →	CARD11	21157432	SIGNOR-248650
AKT1	phosphorylation up-regulates →	CARD11 PSer644	phosphorylation up-regulates →	CARD11	24548923	SIGNOR-276255
AKT1	phosphorylation up-regulates →	CARD11 PSer644	phosphorylation up-regulates →	CARD11	24548923	SIGNOR-276621
PPP2CB	dephosphorylation down-regulates ⊣	CARD11 PSer644	dephosphorylation up-regulates →	CARD11	21157432	SIGNOR-248607
MAP4K1	phosphorylation up-regulates →	CARD11 PSer556	phosphorylation up-regulates →	CARD11	19706536	SIGNOR-276259
AKT1	phosphorylation up-regulates →	CARD11 PSer652	phosphorylation up-regulates →	CARD11	24548923	SIGNOR-276620
AKT1	phosphorylation up-regulates →	CARD11 PSer652	phosphorylation up-regulates →	CARD11	24548923	SIGNOR-276256
PRKCQ	phosphorylation up-regulates →	CARD11 PSer644	phosphorylation up-regulates →	CARD11	21157432	SIGNOR-249193

Regulator	Mechanism/Effect	Target	SIGNOR-ID
MAP4K1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276258
MAP4K1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276257
AKT1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276254
PRKCQ	phosphorylation → down-regulates activity	CARD11	SIGNOR-276298
PPP2CA	dephosphorylation → down-regulates activity	CARD11	SIGNOR-248650
AKT1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276255
AKT1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276621
PPP2CB	dephosphorylation → down-regulates activity	CARD11	SIGNOR-248607
MAP4K1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276259
AKT1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276620
PDPK1	phosphorylation → up-regulates	CARD11	SIGNOR-134866
AKT1	phosphorylation → up-regulates activity	CARD11	SIGNOR-276256
PRKCQ	phosphorylation → up-regulates activity	CARD11	SIGNOR-249193