| Name | PINK1 |
| ID | Q9BXM7 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 156-511 PROSITE-ProRule| Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 17 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 20 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 23 Notice: Undefined index: source in /home/prisca/signor/PhosphoSIGNOR/results/getDomains.php on line 26 |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PINK1 | DNM1L | Ser616 | PIPIMPAsPQKGHAV | phosphorylation up-regulates activity | 32484300 | SIGNOR-279548 |
| PINK1 | HDAC3 | Ser424 | DHDNDKEsDVEI | phosphorylation up-regulates activity | 25305081 | SIGNOR-279093 |
| PINK1 | MAP3K7 | – | phosphorylation up-regulates activity | 22643835 | SIGNOR-279644 | |
| PINK1 | HTRA2 | Ser142 | VPSPPPAsPRSQYNF | phosphorylation up-regulates | 17906618 | SIGNOR-158052 |
| PINK1 | PRKN | Ser65 | NCDLDQQsIVHIVQR | phosphorylation up-regulates | 22724072 | SIGNOR-197976 |
| PINK1 | PRKN | Ser65 | NCDLDQQsIVHIVQR | phosphorylation up-regulates activity | 22724072 | SIGNOR-270345 |
| PINK1 | MFN2 | Ser442 | AEEIRRLsVLVDDYQ | phosphorylation down-regulates quantity | 34275172 | SIGNOR-278208 |
| PINK1 | LETM1 | Thr192 | ILNGHSLtRRERRQF | phosphorylation up-regulates activity | 29123128 | SIGNOR-262540 |
| PINK1 | TP53 | Ser392 | FKTEGPDsD | phosphorylation up-regulates activity | 29033320 | SIGNOR-278418 |
| PINK1 | UBC | Ser65 | DYNIQKEsTLHLVLR | phosphorylation up-regulates activity | 24784582 | SIGNOR-249691 |
| PINK1 | MAPT | – | phosphorylation down-regulates activity | 35059394 | SIGNOR-279250 | |
| PINK1 | TUFM | Ser219 | ETPVIVGsALCALEG | phosphorylation down-regulates activity | 33113344 | SIGNOR-266382 |
| PINK1 | PTEN | Ser179 | RRYVYYYsYLLKNHL | phosphorylation down-regulates activity | 37940999 | SIGNOR-277915 |
| PINK1 | RAB8A | Ser111 | RNIEEHAsADVEKMI | phosphorylation down-regulates activity | 31361120 | SIGNOR-260268 |
| PINK1 | UBA52 | Ser65 | DYNIQKEsTLHLVLR | phosphorylation up-regulates | 24784582 | SIGNOR-270342 |
| PINK1 | TRAP1 | – | phosphorylation up-regulates activity | 28358377 | SIGNOR-278186 | |
| PINK1 | ZNF746 | Ser322 | QATRFFPsPAQEGAW | phosphorylation down-regulates quantity by destabilization | 28122242 | SIGNOR-273724 |
| PINK1 | ZNF746 | Ser613 | APPDPFKsPASKGPL | phosphorylation down-regulates quantity by destabilization | 28122242 | SIGNOR-273725 |
| PINK1 | ZNF746 | Ser322 | QATRFFPsPAQEGAW | phosphorylation up-regulates activity | 32169097 | SIGNOR-278268 |
| PINK1 | ZNF746 | Ser613 | APPDPFKsPASKGPL | phosphorylation up-regulates activity | 32169097 | SIGNOR-278267 |
| PINK1 | RHOT2 | – | phosphorylation down-regulates quantity by destabilization | 22078885 | SIGNOR-272727 | |
| PINK1 | RHOT1 | Ser156 | AKNLKNIsELFYYAQ | phosphorylation down-regulates quantity by destabilization | 22078885 | SIGNOR-273723 |
| PINK1 | RHOT1 | – | phosphorylation down-regulates quantity by destabilization | 22078885 | SIGNOR-272728 | |
| PINK1 | RHOT1 | – | phosphorylation down-regulates quantity by destabilization | 28973175 | SIGNOR-279549 | |
| PINK1 | CRLS1 | – | phosphorylation down-regulates quantity | 24703837 | SIGNOR-280065 | |
| PINK1 | HIF3A | Thr12 | LQRARSTtELRKEKS | phosphorylation down-regulates activity | 27551449 | SIGNOR-263090 |
| PINK1 | Ubiquitin | Ser65 | DYNIQKEsTLHLVLR | phosphorylation up-regulates | 24784582 | SIGNOR-270341 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PINK1 | phosphorylation up-regulates → | DNM1L PSer616 | phosphorylation up-regulates → | DNM1L | 32484300 | SIGNOR-279548 |
| PINK1 | phosphorylation up-regulates → | HDAC3 PSer424 | phosphorylation up-regulates → | HDAC3 | 25305081 | SIGNOR-279093 |
| PINK1 | phosphorylation up-regulates → | HTRA2 PSer142 | phosphorylation up-regulates → | HTRA2 | 17906618 | SIGNOR-158052 |
| PINK1 | phosphorylation up-regulates → | PRKN PSer65 | phosphorylation up-regulates → | PRKN | 22724072 | SIGNOR-197976 |
| PINK1 | phosphorylation up-regulates → | PRKN PSer65 | phosphorylation up-regulates → | PRKN | 22724072 | SIGNOR-270345 |
| PINK1 | phosphorylation up-regulates → | MFN2 PSer442 | phosphorylation down-regulates ⊣ | MFN2 | 34275172 | SIGNOR-278208 |
| PINK1 | phosphorylation up-regulates → | LETM1 PThr192 | phosphorylation up-regulates → | LETM1 | 29123128 | SIGNOR-262540 |
| PINK1 | phosphorylation up-regulates → | TP53 PSer392 | phosphorylation up-regulates → | TP53 | 29033320 | SIGNOR-278418 |
| PINK1 | phosphorylation up-regulates → | UBC PSer65 | phosphorylation up-regulates → | UBC | 24784582 | SIGNOR-249691 |
| PINK1 | phosphorylation up-regulates → | TUFM PSer219 | phosphorylation down-regulates ⊣ | TUFM | 33113344 | SIGNOR-266382 |
| PINK1 | phosphorylation up-regulates → | PTEN PSer179 | phosphorylation down-regulates ⊣ | PTEN | 37940999 | SIGNOR-277915 |
| PINK1 | phosphorylation up-regulates → | RAB8A PSer111 | phosphorylation down-regulates ⊣ | RAB8A | 31361120 | SIGNOR-260268 |
| PINK1 | phosphorylation up-regulates → | UBA52 PSer65 | phosphorylation up-regulates → | UBA52 | 24784582 | SIGNOR-270342 |
| PINK1 | phosphorylation up-regulates → | ZNF746 PSer322 | phosphorylation down-regulates ⊣ | ZNF746 | 28122242 | SIGNOR-273724 |
| PINK1 | phosphorylation up-regulates → | ZNF746 PSer613 | phosphorylation down-regulates ⊣ | ZNF746 | 28122242 | SIGNOR-273725 |
| PINK1 | phosphorylation up-regulates → | ZNF746 PSer322 | phosphorylation up-regulates → | ZNF746 | 32169097 | SIGNOR-278268 |
| PINK1 | phosphorylation up-regulates → | ZNF746 PSer613 | phosphorylation up-regulates → | ZNF746 | 32169097 | SIGNOR-278267 |
| PINK1 | phosphorylation up-regulates → | RHOT1 PSer156 | phosphorylation down-regulates ⊣ | RHOT1 | 22078885 | SIGNOR-273723 |
| PINK1 | phosphorylation up-regulates → | HIF3A PThr12 | phosphorylation down-regulates ⊣ | HIF3A | 27551449 | SIGNOR-263090 |
| PINK1 | phosphorylation up-regulates → | Ubiquitin PSer65 | phosphorylation up-regulates → | Ubiquitin | 24784582 | SIGNOR-270341 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PINK1 | phosphorylation → up-regulates activity | DNM1L | SIGNOR-279548 |
| PINK1 | phosphorylation → up-regulates activity | HDAC3 | SIGNOR-279093 |
| PINK1 | phosphorylation → up-regulates activity | MAP3K7 | SIGNOR-279644 |
| PINK1 | phosphorylation → up-regulates | HTRA2 | SIGNOR-158052 |
| PINK1 | phosphorylation → up-regulates | PRKN | SIGNOR-197976 |
| PINK1 | phosphorylation → up-regulates activity | PRKN | SIGNOR-270345 |
| PINK1 | phosphorylation → down-regulates quantity | MFN2 | SIGNOR-278208 |
| PINK1 | phosphorylation → up-regulates activity | LETM1 | SIGNOR-262540 |
| PINK1 | phosphorylation → up-regulates activity | TP53 | SIGNOR-278418 |
| PINK1 | phosphorylation → up-regulates activity | UBC | SIGNOR-249691 |
| PINK1 | phosphorylation → down-regulates activity | MAPT | SIGNOR-279250 |
| PINK1 | phosphorylation → down-regulates activity | TUFM | SIGNOR-266382 |
| PINK1 | phosphorylation → down-regulates activity | PTEN | SIGNOR-277915 |
| PINK1 | phosphorylation → down-regulates activity | RAB8A | SIGNOR-260268 |
| PINK1 | phosphorylation → up-regulates | UBA52 | SIGNOR-270342 |
| PINK1 | phosphorylation → up-regulates activity | TRAP1 | SIGNOR-278186 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | ZNF746 | SIGNOR-273724 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | ZNF746 | SIGNOR-273725 |
| PINK1 | phosphorylation → up-regulates activity | ZNF746 | SIGNOR-278268 |
| PINK1 | phosphorylation → up-regulates activity | ZNF746 | SIGNOR-278267 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | RHOT2 | SIGNOR-272727 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | RHOT1 | SIGNOR-273723 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | RHOT1 | SIGNOR-272728 |
| PINK1 | phosphorylation down-regulates quantity by destabilization | RHOT1 | SIGNOR-279549 |
| PINK1 | phosphorylation → down-regulates quantity | CRLS1 | SIGNOR-280065 |
| PINK1 | phosphorylation → down-regulates activity | HIF3A | SIGNOR-263090 |
| PINK1 | phosphorylation → up-regulates | Ubiquitin | SIGNOR-270341 |