| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | FANCD2 | Ser882 | DGSKTSSsDTLSEEK | phosphorylation down-regulates activity | 31167143 | SIGNOR-276730 |
| ATM | FANCD2 | Ser1401 | LQGEEIKsQNSQEST | phosphorylation up-regulates | 12086603 | SIGNOR-90109 |
| ATR | FANCD2 | Thr691 | YGLEEYDtQDGIAIN | phosphorylation up-regulates | 16943440 | SIGNOR-149309 |
| ATM | FANCD2 | Ser222 | LPEILGDsQHADVGK | phosphorylation up-regulates | 12086603 | SIGNOR-90121 |
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-107042 |
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-263252 |
| ATM | FANCD2 | Ser1407 | KSQNSQEsTADESED | phosphorylation up-regulates | 12086603 | SIGNOR-90117 |
| ATM | FANCD2 | Ser1404 | EEIKSQNsQESTADE | phosphorylation up-regulates | 12086603 | SIGNOR-90113 |
| CSNK2A1 | FANCD2 | Ser886 | TSSSDTLsEEKNSEC | phosphorylation down-regulates activity | 31167143 | SIGNOR-276731 |
| CSNK2A1 | FANCD2 | Thr896 | KNSECDPtPSHRGQL | phosphorylation down-regulates activity | 31167143 | SIGNOR-276733 |
| CSNK2A1 | FANCD2 | Thr884 | SKTSSSDtLSEEKNS | phosphorylation down-regulates activity | 31167143 | SIGNOR-276732 |
| CSNK2A1 | FANCD2 | Ser898 | SECDPTPsHRGQLNK | phosphorylation down-regulates activity | 31167143 | SIGNOR-276729 |
| ATR | FANCD2 | Ser717 | KDGGPVTsQESGQKL | phosphorylation up-regulates | 16943440 | SIGNOR-149305 |
| CSNK2A1 | FANCD2 | Ser891 | TLSEEKNsECDPTPS | phosphorylation down-regulates activity | 31167143 | SIGNOR-276728 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PSer882 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276730 |
| ATM | phosphorylation up-regulates → | FANCD2 PSer1401 | phosphorylation up-regulates → | FANCD2 | 12086603 | SIGNOR-90109 |
| ATR | phosphorylation up-regulates → | FANCD2 PThr691 | phosphorylation up-regulates → | FANCD2 | 16943440 | SIGNOR-149309 |
| ATM | phosphorylation up-regulates → | FANCD2 PSer222 | phosphorylation up-regulates → | FANCD2 | 12086603 | SIGNOR-90121 |
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-107042 |
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-263252 |
| ATM | phosphorylation up-regulates → | FANCD2 PSer1407 | phosphorylation up-regulates → | FANCD2 | 12086603 | SIGNOR-90117 |
| ATM | phosphorylation up-regulates → | FANCD2 PSer1404 | phosphorylation up-regulates → | FANCD2 | 12086603 | SIGNOR-90113 |
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PSer886 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276731 |
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PThr896 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276733 |
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PThr884 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276732 |
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PSer898 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276729 |
| ATR | phosphorylation up-regulates → | FANCD2 PSer717 | phosphorylation up-regulates → | FANCD2 | 16943440 | SIGNOR-149305 |
| CSNK2A1 | phosphorylation up-regulates → | FANCD2 PSer891 | phosphorylation down-regulates ⊣ | FANCD2 | 31167143 | SIGNOR-276728 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276730 |
| ATM | phosphorylation → up-regulates | FANCD2 | SIGNOR-90109 |
| ATR | phosphorylation → up-regulates | FANCD2 | SIGNOR-149309 |
| ATM | phosphorylation → up-regulates | FANCD2 | SIGNOR-90121 |
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-107042 |
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-263252 |
| ATM | phosphorylation → up-regulates | FANCD2 | SIGNOR-90117 |
| ATM | phosphorylation → up-regulates | FANCD2 | SIGNOR-90113 |
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276731 |
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276733 |
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276732 |
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276729 |
| ATR | phosphorylation → up-regulates | FANCD2 | SIGNOR-149305 |
| CSNK2A1 | phosphorylation → down-regulates activity | FANCD2 | SIGNOR-276728 |
