| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-107042 |
| CHEK1 | FANCD2 | Ser331 | KSKGRASsSGNQESS | phosphorylation up-regulates activity | 19861535 | SIGNOR-263252 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-107042 |
| CHEK1 | phosphorylation up-regulates → | FANCD2 PSer331 | phosphorylation up-regulates → | FANCD2 | 19861535 | SIGNOR-263252 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-107042 |
| CHEK1 | phosphorylation → up-regulates activity | FANCD2 | SIGNOR-263252 |