| Name | WNK3 |
| ID | Q9BYP7 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 147-405 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK3 | SLC12A2 | – | phosphorylation up-regulates activity | 21613606 | SIGNOR-264625 | |
| WNK3 | SLC12A3 | – | phosphorylation up-regulates activity | 21613606 | SIGNOR-264624 | |
| WNK3 | SLC12A1 | – | phosphorylation up-regulates activity | 21613606 | SIGNOR-264626 | |
| WNK3 | SLC12A5 | – | phosphorylation down-regulates activity | 21613606 | SIGNOR-264628 | |
| WNK3 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates activity | 22032326 | SIGNOR-260789 |
| WNK3 | SLC12A6 | – | phosphorylation down-regulates activity | 21613606 | SIGNOR-264629 | |
| WNK3 | SLC12A6 | Ser96 | IEDLSQNsITGEHSQ | phosphorylation down-regulates activity | 24043619 | SIGNOR-260911 |
| WNK3 | SLC12A6 | Thr1048 | YQEKVHMtWTKDKYM | phosphorylation down-regulates activity | 24043619 | SIGNOR-260910 |
| WNK3 | SLC12A6 | Thr991 | SAYTYERtLMMEQRS | phosphorylation down-regulates activity | 24043619 | SIGNOR-260912 |
| WNK3 | SLC12A4 | – | phosphorylation down-regulates activity | 21613606 | SIGNOR-264627 | |
| WNK3 | SLC12A7 | – | phosphorylation down-regulates activity | 21613606 | SIGNOR-264630 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK3 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 22032326 | SIGNOR-260789 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PSer96 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260911 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PThr1048 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260910 |
| WNK3 | phosphorylation up-regulates → | SLC12A6 PThr991 | phosphorylation down-regulates ⊣ | SLC12A6 | 24043619 | SIGNOR-260912 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK3 | phosphorylation → up-regulates activity | SLC12A2 | SIGNOR-264625 |
| WNK3 | phosphorylation → up-regulates activity | SLC12A3 | SIGNOR-264624 |
| WNK3 | phosphorylation → up-regulates activity | SLC12A1 | SIGNOR-264626 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A5 | SIGNOR-264628 |
| WNK3 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260789 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-264629 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260911 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260910 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A6 | SIGNOR-260912 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A4 | SIGNOR-264627 |
| WNK3 | phosphorylation → down-regulates activity | SLC12A7 | SIGNOR-264630 |