| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 12058027 | SIGNOR-275951 |
| PRKCH | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 12058027 | SIGNOR-89427 |
| PRKCA | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 12058027 | SIGNOR-275954 |
| PRKCH | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 12058027 | SIGNOR-275957 |
| PRKCE | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates activity | 12058027 | SIGNOR-275960 |
| PRKCE | PRKD2 | Ser710 | GEKSFRRsVVGTPAY | phosphorylation up-regulates | 12058027 | SIGNOR-89415 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275951 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89427 |
| PRKCA | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275954 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275957 |
| PRKCE | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275960 |
| PRKCE | phosphorylation up-regulates → | PRKD2 PSer710 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89415 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275951 |
| PRKCH | phosphorylation → up-regulates | PRKD2 | SIGNOR-89427 |
| PRKCA | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275954 |
| PRKCH | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275957 |
| PRKCE | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275960 |
| PRKCE | phosphorylation → up-regulates | PRKD2 | SIGNOR-89415 |
