| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates activity | 12058027 | SIGNOR-275950 |
| PRKCE | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates activity | 12058027 | SIGNOR-275959 |
| PRKD2 | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates | 11062248 | SIGNOR-83834 |
| PRKCE | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates | 12058027 | SIGNOR-89419 |
| PRKCH | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates activity | 12058027 | SIGNOR-275956 |
| PRKCH | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates | 12058027 | SIGNOR-89431 |
| PRKCA | PRKD2 | Ser876 | QGLAERIsVL | phosphorylation up-regulates activity | 12058027 | SIGNOR-275953 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PKA | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275950 |
| PRKCE | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275959 |
| PRKD2 | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 11062248 | SIGNOR-83834 |
| PRKCE | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89419 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275956 |
| PRKCH | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-89431 |
| PRKCA | phosphorylation up-regulates → | PRKD2 PSer876 | phosphorylation up-regulates → | PRKD2 | 12058027 | SIGNOR-275953 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PKA | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275950 |
| PRKCE | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275959 |
| PRKD2 | phosphorylation → up-regulates | PRKD2 | SIGNOR-83834 |
| PRKCE | phosphorylation → up-regulates | PRKD2 | SIGNOR-89419 |
| PRKCH | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275956 |
| PRKCH | phosphorylation → up-regulates | PRKD2 | SIGNOR-89431 |
| PRKCA | phosphorylation → up-regulates activity | PRKD2 | SIGNOR-275953 |
