Entity Details

Name FOXP3
ID Q9BZS1
Role substrate
Enzymatic Domains
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Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
GSK3BFOXP3Ser274TKASSVAsSDKGSCCphosphorylation
down-regulates quantity by destabilization		27432879SIGNOR-277245
GSK3BFOXP3Ser270KMALTKAsSVASSDKphosphorylation
down-regulates quantity by destabilization		27432879SIGNOR-277244
LCKFOXP3Tyr342NMRPPFTyATLIRWAphosphorylation
down-regulates		24155921SIGNOR-203089
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
GSK3Bphosphorylation
up-regulates
→
FOXP3
PSer274		phosphorylation
down-regulates
⊣		FOXP327432879SIGNOR-277245
GSK3Bphosphorylation
up-regulates
→
FOXP3
PSer270		phosphorylation
down-regulates
⊣		FOXP327432879SIGNOR-277244
LCKphosphorylation
up-regulates
→
FOXP3
PTyr342		phosphorylation
down-regulates
⊣		FOXP324155921SIGNOR-203089
Regulator Mechanism/Effect Target SIGNOR-ID
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		FOXP3SIGNOR-277245
GSK3Bphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		FOXP3SIGNOR-277244
LCKphosphorylation
img/direct_inhibition.png
down-regulates 		FOXP3SIGNOR-203089