| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | AMBRA1 | Ser52 | KRVELPDsPRSTFLL | phosphorylation down-regulates activity | 23524951 | SIGNOR-272986 |
| CyclinB/CDK1 | AMBRA1 | Ser1252 | QPTLPSSsPVPIPVS | phosphorylation up-regulates activity | 37584777 | SIGNOR-272969 |
| CHUK | AMBRA1 | Ser1043 | CRPEALNsGVEYYWD | phosphorylation up-regulates activity | 30217973 | SIGNOR-272974 |
| ULK1 | AMBRA1 | – | phosphorylation up-regulates | 20921139 | SIGNOR-168292 | |
| ULK1/Atg13/Fip200 | AMBRA1 | – | phosphorylation up-regulates activity | 20921139 | SIGNOR-219388 | |
| CDK1 | AMBRA1 | Ser1252 | QPTLPSSsPVPIPVS | phosphorylation up-regulates activity | 37584777 | SIGNOR-272968 |
| CyclinB/CDK1 | AMBRA1 | Thr1238 | ASWDQPGtPGREPTQ | phosphorylation up-regulates activity | 37584777 | SIGNOR-272967 |
| CDK1 | AMBRA1 | Thr1238 | ASWDQPGtPGREPTQ | phosphorylation up-regulates activity | 37584777 | SIGNOR-272966 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MTOR | phosphorylation up-regulates → | AMBRA1 PSer52 | phosphorylation down-regulates ⊣ | AMBRA1 | 23524951 | SIGNOR-272986 |
| CyclinB/CDK1 | phosphorylation up-regulates → | AMBRA1 PSer1252 | phosphorylation up-regulates → | AMBRA1 | 37584777 | SIGNOR-272969 |
| CHUK | phosphorylation up-regulates → | AMBRA1 PSer1043 | phosphorylation up-regulates → | AMBRA1 | 30217973 | SIGNOR-272974 |
| CDK1 | phosphorylation up-regulates → | AMBRA1 PSer1252 | phosphorylation up-regulates → | AMBRA1 | 37584777 | SIGNOR-272968 |
| CyclinB/CDK1 | phosphorylation up-regulates → | AMBRA1 PThr1238 | phosphorylation up-regulates → | AMBRA1 | 37584777 | SIGNOR-272967 |
| CDK1 | phosphorylation up-regulates → | AMBRA1 PThr1238 | phosphorylation up-regulates → | AMBRA1 | 37584777 | SIGNOR-272966 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MTOR | phosphorylation → down-regulates activity | AMBRA1 | SIGNOR-272986 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272969 |
| CHUK | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272974 |
| ULK1 | phosphorylation → up-regulates | AMBRA1 | SIGNOR-168292 |
| ULK1/Atg13/Fip200 | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-219388 |
| CDK1 | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272968 |
| CyclinB/CDK1 | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272967 |
| CDK1 | phosphorylation → up-regulates activity | AMBRA1 | SIGNOR-272966 |
