| Name | CTDSP1 |
| ID | Q9GZU7 |
| Role | phosphatase |
| Enzymatic Domains |
FCP1 homology 86-244 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | POLR2A | Ser1616 | TPQSPSYsPTSPSYS | dephosphorylation up-regulates activity | 17157258 | SIGNOR-248767 |
| CTDSP1 | POLR2A | Ser1619 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248768 |
| CTDSP1 | POLR2A | Ser1623 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248780 |
| CTDSP1 | POLR2A | Ser1626 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248769 |
| CTDSP1 | POLR2A | Ser1644 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248781 |
| CTDSP1 | POLR2A | Ser1647 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248770 |
| CTDSP1 | POLR2A | Ser1651 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248782 |
| CTDSP1 | POLR2A | Ser1654 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248771 |
| CTDSP1 | POLR2A | Ser1665 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248783 |
| CTDSP1 | POLR2A | Ser1668 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248772 |
| CTDSP1 | POLR2A | Ser1672 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248784 |
| CTDSP1 | POLR2A | Ser1675 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248773 |
| CTDSP1 | POLR2A | Ser1693 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248785 |
| CTDSP1 | POLR2A | Ser1696 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248774 |
| CTDSP1 | POLR2A | Ser1714 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248786 |
| CTDSP1 | POLR2A | Ser1717 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248775 |
| CTDSP1 | POLR2A | Ser1721 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248787 |
| CTDSP1 | POLR2A | Ser1724 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248776 |
| CTDSP1 | POLR2A | Ser1735 | SPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248788 |
| CTDSP1 | POLR2A | Ser1738 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248777 |
| CTDSP1 | POLR2A | Ser1763 | TPTSPSYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248789 |
| CTDSP1 | POLR2A | Ser1766 | SPSYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248778 |
| CTDSP1 | POLR2A | Ser1784 | TPTSPNYsPTSPSYS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248790 |
| CTDSP1 | POLR2A | Ser1787 | SPNYSPTsPSYSPTS | dephosphorylation up-regulates activity | 22137580 | SIGNOR-248779 |
| CTDSP1 | PRKDC | – | dephosphorylation up-regulates activity | 32764831 | SIGNOR-277101 | |
| CTDSP1 | SMAD3 | Ser204 | NHSMDAGsPNLSPNP | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248791 |
| CTDSP1 | SMAD3 | Ser208 | DAGSPNLsPNPMSPA | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248792 |
| CTDSP1 | SMAD3 | Ser213 | NLSPNPMsPAHNNLD | dephosphorylation up-regulates activity | 17035229 | SIGNOR-248793 |
| CTDSP1 | TWIST1 | Ser68 | GGGDEPGsPAQGKRG | dephosphorylation down-regulates activity | 26975371 | SIGNOR-245962 |
| CTDSP1 | SMAD2 | Ser245 | NQSMDTGsPAELSPT | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248795 |
| CTDSP1 | SMAD2 | Ser250 | TGSPAELsPTTLSPV | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248796 |
| CTDSP1 | SMAD2 | Ser255 | ELSPTTLsPVNHSLD | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248797 |
| CTDSP1 | SMAD2 | Thr220 | QSNYIPEtPPPGYIS | dephosphorylation down-regulates activity | 17035229 | SIGNOR-248794 |
| CTDSP1 | SMAD1 | – | dephosphorylation down-regulates | 16882717 | SIGNOR-148396 | |
| CTDSP1 | SMAD1 | Ser187 | NSHPFPHsPNSSYPN | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248798 |
| CTDSP1 | SMAD1 | Ser195 | PNSSYPNsPGSSSST | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248799 |
| CTDSP1 | SMAD1 | Ser206 | SSSTYPHsPTSSDPG | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248800 |
| CTDSP1 | SMAD1 | Ser214 | PTSSDPGsPFQMPAD | dephosphorylation down-regulates activity | 17085434 | SIGNOR-248801 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1616 | dephosphorylation down-regulates ⊣ | POLR2A | 17157258 | SIGNOR-248767 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1619 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248768 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1623 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248780 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1626 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248769 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1644 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248781 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1647 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248770 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1651 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248782 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1654 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248771 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1665 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248783 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1668 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248772 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1672 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248784 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1675 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248773 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1693 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248785 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1696 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248774 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1714 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248786 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1717 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248775 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1721 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248787 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1724 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248776 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1735 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248788 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1738 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248777 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1763 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248789 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1766 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248778 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1784 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248790 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | POLR2A PSer1787 | dephosphorylation down-regulates ⊣ | POLR2A | 22137580 | SIGNOR-248779 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer204 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248791 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer208 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248792 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD3 PSer213 | dephosphorylation down-regulates ⊣ | SMAD3 | 17035229 | SIGNOR-248793 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | TWIST1 PSer68 | dephosphorylation up-regulates → | TWIST1 | 26975371 | SIGNOR-245962 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer245 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248795 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer250 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248796 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PSer255 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248797 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD2 PThr220 | dephosphorylation up-regulates → | SMAD2 | 17035229 | SIGNOR-248794 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer187 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248798 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer195 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248799 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer206 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248800 |
| CTDSP1 | dephosphorylation down-regulates ⊣ | SMAD1 PSer214 | dephosphorylation up-regulates → | SMAD1 | 17085434 | SIGNOR-248801 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248767 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248768 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248780 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248769 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248781 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248770 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248782 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248771 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248783 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248772 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248784 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248773 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248785 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248774 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248786 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248775 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248787 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248776 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248788 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248777 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248789 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248778 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248790 |
| CTDSP1 | dephosphorylation → up-regulates activity | POLR2A | SIGNOR-248779 |
| CTDSP1 | dephosphorylation → up-regulates activity | PRKDC | SIGNOR-277101 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248791 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248792 |
| CTDSP1 | dephosphorylation → up-regulates activity | SMAD3 | SIGNOR-248793 |
| CTDSP1 | dephosphorylation → down-regulates activity | TWIST1 | SIGNOR-245962 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248795 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248796 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248797 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD2 | SIGNOR-248794 |
| CTDSP1 | dephosphorylation down-regulates | SMAD1 | SIGNOR-148396 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248798 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248799 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248800 |
| CTDSP1 | dephosphorylation → down-regulates activity | SMAD1 | SIGNOR-248801 |