| Name | WWTR1 |
| ID | Q9GZV5 |
| Role | substrate |
| Enzymatic Domains |
WW 124-157 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | WWTR1 | Thr346 | TGENAGQtPMNINPQ | phosphorylation down-regulates activity | 26375055 | SIGNOR-276521 |
| GSK3B | WWTR1 | Ser62 | EPDSGSHsRQSSTDS | phosphorylation down-regulates quantity by destabilization | 22692215 | SIGNOR-277647 |
| CDK1 | WWTR1 | Thr285 | AVNPPTMtPDMRSIT | phosphorylation down-regulates quantity by destabilization | 26183396 | SIGNOR-276925 |
| CDK1 | WWTR1 | Thr326 | GCYSVPTtPEDFLSN | phosphorylation down-regulates activity | 26375055 | SIGNOR-276519 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197651 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 21808241 | SIGNOR-175787 |
| CyclinB/CDK1 | WWTR1 | Thr346 | TGENAGQtPMNINPQ | phosphorylation down-regulates activity | 26375055 | SIGNOR-276525 |
| PPP1CA | WWTR1 | Ser89 | AQHVRSHsSPASLQL | dephosphorylation up-regulates activity | 21189257 | SIGNOR-277116 |
| PPP1CA | WWTR1 | Ser311 | PYHSREQsTDSGLGL | dephosphorylation up-regulates activity | 21189257 | SIGNOR-277115 |
| CyclinB/CDK1 | WWTR1 | Thr326 | GCYSVPTtPEDFLSN | phosphorylation down-regulates activity | 26375055 | SIGNOR-276523 |
| YES1 | WWTR1 | Tyr305 | PFLNGGPyHSREQST | phosphorylation up-regulates activity | 35041461 | SIGNOR-277654 |
| CyclinB/CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates activity | 26375055 | SIGNOR-276524 |
| LATS1 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 21808241 | SIGNOR-175783 |
| LATS1/2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates activity | 22658639 | SIGNOR-256187 |
| CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates activity | 26375055 | SIGNOR-276520 |
| LATS1 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197643 |
| CSNK1E | WWTR1 | Ser314 | SREQSTDsGLGLGCY | phosphorylation down-regulates | 24715453 | SIGNOR-230747 |
| CDK1 | WWTR1 | Ser90 | QHVRSHSsPASLQLG | phosphorylation down-regulates quantity by destabilization | 26183396 | SIGNOR-276926 |
| CDK1 | WWTR1 | Ser90 | QHVRSHSsPASLQLG | phosphorylation down-regulates activity | 26375055 | SIGNOR-276518 |
| CyclinB/CDK1 | WWTR1 | Ser90 | QHVRSHSsPASLQLG | phosphorylation down-regulates activity | 26375055 | SIGNOR-276522 |
| GSK3B | WWTR1 | Ser58 | SFFKEPDsGSHSRQS | phosphorylation down-regulates quantity by destabilization | 22692215 | SIGNOR-277646 |
| CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates quantity by destabilization | 26183396 | SIGNOR-276927 |
| CSNK1D | WWTR1 | Ser314 | SREQSTDsGLGLGCY | phosphorylation down-regulates | 24715453 | SIGNOR-234438 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | WWTR1 PThr346 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276521 |
| GSK3B | phosphorylation up-regulates → | WWTR1 PSer62 | phosphorylation down-regulates ⊣ | WWTR1 | 22692215 | SIGNOR-277647 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PThr285 | phosphorylation down-regulates ⊣ | WWTR1 | 26183396 | SIGNOR-276925 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PThr326 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276519 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-197651 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 21808241 | SIGNOR-175787 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PThr346 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276525 |
| PPP1CA | dephosphorylation down-regulates ⊣ | WWTR1 PSer89 | dephosphorylation down-regulates ⊣ | WWTR1 | 21189257 | SIGNOR-277116 |
| PPP1CA | dephosphorylation down-regulates ⊣ | WWTR1 PSer311 | dephosphorylation down-regulates ⊣ | WWTR1 | 21189257 | SIGNOR-277115 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PThr326 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276523 |
| YES1 | phosphorylation up-regulates → | WWTR1 PTyr305 | phosphorylation up-regulates → | WWTR1 | 35041461 | SIGNOR-277654 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276524 |
| LATS1 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 21808241 | SIGNOR-175783 |
| LATS1/2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-256187 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276520 |
| LATS1 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-197643 |
| CSNK1E | phosphorylation up-regulates → | WWTR1 PSer314 | phosphorylation down-regulates ⊣ | WWTR1 | 24715453 | SIGNOR-230747 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer90 | phosphorylation down-regulates ⊣ | WWTR1 | 26183396 | SIGNOR-276926 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer90 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276518 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PSer90 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276522 |
| GSK3B | phosphorylation up-regulates → | WWTR1 PSer58 | phosphorylation down-regulates ⊣ | WWTR1 | 22692215 | SIGNOR-277646 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26183396 | SIGNOR-276927 |
| CSNK1D | phosphorylation up-regulates → | WWTR1 PSer314 | phosphorylation down-regulates ⊣ | WWTR1 | 24715453 | SIGNOR-234438 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276521 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | WWTR1 | SIGNOR-277647 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | WWTR1 | SIGNOR-276925 |
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276519 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-197651 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-175787 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276525 |
| PPP1CA | dephosphorylation → up-regulates activity | WWTR1 | SIGNOR-277116 |
| PPP1CA | dephosphorylation → up-regulates activity | WWTR1 | SIGNOR-277115 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276523 |
| YES1 | phosphorylation → up-regulates activity | WWTR1 | SIGNOR-277654 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276524 |
| LATS1 | phosphorylation down-regulates | WWTR1 | SIGNOR-175783 |
| LATS1/2 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-256187 |
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276520 |
| LATS1 | phosphorylation down-regulates | WWTR1 | SIGNOR-197643 |
| CSNK1E | phosphorylation down-regulates | WWTR1 | SIGNOR-230747 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | WWTR1 | SIGNOR-276926 |
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276518 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276522 |
| GSK3B | phosphorylation down-regulates quantity by destabilization | WWTR1 | SIGNOR-277646 |
| CDK1 | phosphorylation down-regulates quantity by destabilization | WWTR1 | SIGNOR-276927 |
| CSNK1D | phosphorylation down-regulates | WWTR1 | SIGNOR-234438 |