| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates activity | 26375055 | SIGNOR-276524 |
| CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates activity | 26375055 | SIGNOR-276520 |
| CDK1 | WWTR1 | Ser105 | TGAGAAGsPAQQHAH | phosphorylation down-regulates quantity by destabilization | 26183396 | SIGNOR-276927 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276524 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276520 |
| CDK1 | phosphorylation up-regulates → | WWTR1 PSer105 | phosphorylation down-regulates ⊣ | WWTR1 | 26183396 | SIGNOR-276927 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276524 |
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276520 |
| CDK1 | phosphorylation![]() down-regulates quantity by destabilization | WWTR1 | SIGNOR-276927 |