| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS1 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 21808241 | SIGNOR-175783 |
| LATS1/2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates activity | 22658639 | SIGNOR-256187 |
| LATS1 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197643 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 22658639 | SIGNOR-197651 |
| LATS2 | WWTR1 | Ser89 | AQHVRSHsSPASLQL | phosphorylation down-regulates | 21808241 | SIGNOR-175787 |
| PPP1CA | WWTR1 | Ser89 | AQHVRSHsSPASLQL | dephosphorylation up-regulates activity | 21189257 | SIGNOR-277116 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LATS1 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 21808241 | SIGNOR-175783 |
| LATS1/2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-256187 |
| LATS1 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-197643 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 22658639 | SIGNOR-197651 |
| LATS2 | phosphorylation up-regulates → | WWTR1 PSer89 | phosphorylation down-regulates ⊣ | WWTR1 | 21808241 | SIGNOR-175787 |
| PPP1CA | dephosphorylation down-regulates ⊣ | WWTR1 PSer89 | dephosphorylation down-regulates ⊣ | WWTR1 | 21189257 | SIGNOR-277116 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LATS1 | phosphorylation down-regulates | WWTR1 | SIGNOR-175783 |
| LATS1/2 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-256187 |
| LATS1 | phosphorylation down-regulates | WWTR1 | SIGNOR-197643 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-197651 |
| LATS2 | phosphorylation down-regulates | WWTR1 | SIGNOR-175787 |
| PPP1CA | dephosphorylation → up-regulates activity | WWTR1 | SIGNOR-277116 |
