| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | WWTR1 | Thr326 | GCYSVPTtPEDFLSN | phosphorylation down-regulates activity | 26375055 | SIGNOR-276519 |
| CyclinB/CDK1 | WWTR1 | Thr326 | GCYSVPTtPEDFLSN | phosphorylation down-regulates activity | 26375055 | SIGNOR-276523 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK1 | phosphorylation up-regulates → | WWTR1 PThr326 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276519 |
| CyclinB/CDK1 | phosphorylation up-regulates → | WWTR1 PThr326 | phosphorylation down-regulates ⊣ | WWTR1 | 26375055 | SIGNOR-276523 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276519 |
| CyclinB/CDK1 | phosphorylation → down-regulates activity | WWTR1 | SIGNOR-276523 |