| Name | RACGAP1 |
| ID | Q9H0H5 |
| Role | substrate |
| Enzymatic Domains |
Rho-GAP 349-539 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | RACGAP1 | Thr145 | AGNKRLStIDESGSI | phosphorylation up-regulates activity | 14744859 | SIGNOR-250589 |
| PLK1 | RACGAP1 | Thr260 | QPWNSDStLNSRQLE | phosphorylation up-regulates | 19468302 | SIGNOR-185758 |
| AURKB | RACGAP1 | Ser187 | REKRRSTsRQFVDGP | phosphorylation up-regulates activity | 14744859 | SIGNOR-250588 |
| AURKB | RACGAP1 | Thr186 | KREKRRStSRQFVDG | phosphorylation up-regulates activity | 14744859 | SIGNOR-250590 |
| PLK1 | RACGAP1 | Ser214 | AVDQGNEsIVAKTTV | phosphorylation up-regulates | 19468302 | SIGNOR-185754 |
| PPP2CA | RACGAP1 | Thr588 | PEHQLLKtPSSSSLS | dephosphorylation down-regulates | 18201571 | SIGNOR-160402 |
| AURKB | RACGAP1 | Ser144 | NAGNKRLsTIDESGS | phosphorylation up-regulates activity | 14744859 | SIGNOR-250586 |
| AURKB | RACGAP1 | Ser185 | KKREKRRsTSRQFVD | phosphorylation up-regulates activity | 14744859 | SIGNOR-250587 |
| PLK1 | RACGAP1 | Ser170 | ESLDWDSsLVKTFKL | phosphorylation up-regulates | 19468302 | SIGNOR-185750 |
| PPP2CA | RACGAP1 | Ser387 | ETGLYRIsGCDRTVK | dephosphorylation down-regulates | 18201571 | SIGNOR-160398 |
| PLK1 | RACGAP1 | Ser157 | GSILSDIsFDKTDES | phosphorylation up-regulates | 19468302 | SIGNOR-185746 |
| AURKB | RACGAP1 | Ser387 | ETGLYRIsGCDRTVK | phosphorylation up-regulates activity | 12689593 | SIGNOR-100569 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| AURKB | phosphorylation up-regulates → | RACGAP1 PThr145 | phosphorylation up-regulates → | RACGAP1 | 14744859 | SIGNOR-250589 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PThr260 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185758 |
| AURKB | phosphorylation up-regulates → | RACGAP1 PSer187 | phosphorylation up-regulates → | RACGAP1 | 14744859 | SIGNOR-250588 |
| AURKB | phosphorylation up-regulates → | RACGAP1 PThr186 | phosphorylation up-regulates → | RACGAP1 | 14744859 | SIGNOR-250590 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer214 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185754 |
| PPP2CA | dephosphorylation down-regulates ⊣ | RACGAP1 PThr588 | dephosphorylation up-regulates → | RACGAP1 | 18201571 | SIGNOR-160402 |
| AURKB | phosphorylation up-regulates → | RACGAP1 PSer144 | phosphorylation up-regulates → | RACGAP1 | 14744859 | SIGNOR-250586 |
| AURKB | phosphorylation up-regulates → | RACGAP1 PSer185 | phosphorylation up-regulates → | RACGAP1 | 14744859 | SIGNOR-250587 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer170 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185750 |
| PPP2CA | dephosphorylation down-regulates ⊣ | RACGAP1 PSer387 | dephosphorylation up-regulates → | RACGAP1 | 18201571 | SIGNOR-160398 |
| PLK1 | phosphorylation up-regulates → | RACGAP1 PSer157 | phosphorylation up-regulates → | RACGAP1 | 19468302 | SIGNOR-185746 |
| AURKB | phosphorylation up-regulates → | RACGAP1 PSer387 | phosphorylation up-regulates → | RACGAP1 | 12689593 | SIGNOR-100569 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-250589 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185758 |
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-250588 |
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-250590 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185754 |
| PPP2CA | dephosphorylation![]() down-regulates | RACGAP1 | SIGNOR-160402 |
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-250586 |
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-250587 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185750 |
| PPP2CA | dephosphorylation![]() down-regulates | RACGAP1 | SIGNOR-160398 |
| PLK1 | phosphorylation → up-regulates | RACGAP1 | SIGNOR-185746 |
| AURKB | phosphorylation → up-regulates activity | RACGAP1 | SIGNOR-100569 |