| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PTPN1 | TRPV6 | – | dephosphorylation down-regulates | 17197020 | SIGNOR-151711 | |
| PRKCB | TRPV6 | Thr728 | MPSVSRStSRSSANW | phosphorylation down-regulates activity | 19805577 | SIGNOR-276266 |
| PTPN1 | TRPV6 | – | dephosphorylation down-regulates activity | 17197020 | SIGNOR-248433 | |
| PRKCB | TRPV6 | Ser184 | LARRASVsARATGTA | phosphorylation down-regulates activity | 19805577 | SIGNOR-276265 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKCB | phosphorylation up-regulates → | TRPV6 PThr728 | phosphorylation down-regulates ⊣ | TRPV6 | 19805577 | SIGNOR-276266 |
| PRKCB | phosphorylation up-regulates → | TRPV6 PSer184 | phosphorylation down-regulates ⊣ | TRPV6 | 19805577 | SIGNOR-276265 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PTPN1 | dephosphorylation![]() down-regulates | TRPV6 | SIGNOR-151711 |
| PRKCB | phosphorylation → down-regulates activity | TRPV6 | SIGNOR-276266 |
| PTPN1 | dephosphorylation → down-regulates activity | TRPV6 | SIGNOR-248433 |
| PRKCB | phosphorylation → down-regulates activity | TRPV6 | SIGNOR-276265 |