| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | TSPYL2 | Ser20 | RRLSSSEsPQRDPPP | phosphorylation up-regulates activity | 11395479 | SIGNOR-250752 |
| CyclinA2/CDK2 | TSPYL2 | Thr340 | GRLVSHStPIRWHRG | phosphorylation up-regulates activity | 11395479 | SIGNOR-250753 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation up-regulates → | TSPYL2 PSer20 | phosphorylation up-regulates → | TSPYL2 | 11395479 | SIGNOR-250752 |
| CyclinA2/CDK2 | phosphorylation up-regulates → | TSPYL2 PThr340 | phosphorylation up-regulates → | TSPYL2 | 11395479 | SIGNOR-250753 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | TSPYL2 | SIGNOR-250752 |
| CyclinA2/CDK2 | phosphorylation → up-regulates activity | TSPYL2 | SIGNOR-250753 |
