| Name | HIPK2 |
| ID | Q9H2X6 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 199-527 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | CBX4 | – | phosphorylation up-regulates activity | 17018294 | SIGNOR-278484 | |
| HIPK2 | PPM1D | Ser54 | QPLPPRPsPAALPGG | phosphorylation down-regulates quantity by destabilization | 23871434 | SIGNOR-275480 |
| HIPK2 | PPM1D | Ser85 | PLPDAGAsPAPSRCC | phosphorylation down-regulates quantity by destabilization | 23871434 | SIGNOR-275481 |
| HIPK2 | PPM1D | Ser54 | QPLPPRPsPAALPGG | phosphorylation down-regulates quantity by destabilization | 27308327 | SIGNOR-278229 |
| HIPK2 | PPM1D | Ser85 | PLPDAGAsPAPSRCC | phosphorylation down-regulates quantity by destabilization | 27308327 | SIGNOR-278230 |
| HIPK2 | HDAC3 | Ser374 | KMLNHAPsVQIHDVP | phosphorylation down-regulates activity | 34244427 | SIGNOR-277568 |
| HIPK2 | TP53 | Ser46 | AMDDLMLsPDDIEQW | phosphorylation up-regulates | 17210684 | SIGNOR-151930 |
| HIPK2 | BCHE | – | phosphorylation down-regulates quantity | 25210797 | SIGNOR-279190 | |
| HIPK2 | TCF3 | – | phosphorylation down-regulates activity | 21285352 | SIGNOR-279193 | |
| HIPK2 | CREB1 | Ser257 | PGVVMASsPALPTQP | phosphorylation up-regulates | 20573984 | SIGNOR-166338 |
| HIPK2 | HMGA1 | Ser36 | PRKQPPVsPGTALVG | phosphorylation down-regulates | 17960875 | SIGNOR-158616 |
| HIPK2 | HMGA1 | Thr53 | KEPSEVPtPKRPRGR | phosphorylation down-regulates | 17960875 | SIGNOR-158620 |
| HIPK2 | PAX6 | Thr281 | QRRQASNtPSHIPIS | phosphorylation up-regulates activity | 16407227 | SIGNOR-251269 |
| HIPK2 | PAX6 | Thr304 | QPIPQPTtPVSSFTS | phosphorylation up-regulates activity | 16407227 | SIGNOR-251270 |
| HIPK2 | PAX6 | Thr373 | GRSYDTYtPPHMQTH | phosphorylation up-regulates activity | 16407227 | SIGNOR-251271 |
| HIPK2 | PML | Ser38 | EGRQPSPsPSPTERA | phosphorylation up-regulates | 19015637 | SIGNOR-182428 |
| HIPK2 | PML | Ser8 | MEPAPARsPRPQQDP | phosphorylation up-regulates | 19015637 | SIGNOR-182432 |
| HIPK2 | CDKN1B | Ser10 | NVRVSNGsPSLERMD | phosphorylation up-regulates | 21715331 | SIGNOR-174617 |
| HIPK2 | MECP2 | Ser80 | AVPEASAsPKQRRSI | phosphorylation up-regulates activity | 19820693 | SIGNOR-264549 |
| HIPK2 | PDX1 | Ser268 | LPPGLSAsPQPSSVA | phosphorylation unknown | 20637728 | SIGNOR-255539 |
| HIPK2 | MDM2 | – | phosphorylation down-regulates activity | 16212962 | SIGNOR-279465 | |
| HIPK2 | MEF2C | – | phosphorylation down-regulates activity | 23620283 | SIGNOR-279192 | |
| HIPK2 | FOXM1 | – | phosphorylation up-regulates activity | 30609136 | SIGNOR-278944 | |
| HIPK2 | EP300 | – | phosphorylation up-regulates activity | 20573984 | SIGNOR-278943 | |
| HIPK2 | CTBP1 | Ser422 | AHPPHAPsPGQTVKP | phosphorylation down-regulates | 15708980 | SIGNOR-134040 |
| HIPK2 | DAZAP2 | – | phosphorylation down-regulates activity | 33591310 | SIGNOR-279335 | |
| HIPK2 | CREBBP | – | phosphorylation up-regulates activity | 26247811 | SIGNOR-279191 | |
| HIPK2 | HIPK2 | Ser882 | IVIPDTPsPTVSVIT | phosphorylation up-regulates activity | 24145406 | SIGNOR-276600 |
| HIPK2 | HIPK2 | Thr880 | QTIVIPDtPSPTVSV | phosphorylation up-regulates activity | 24145406 | SIGNOR-276601 |
| HIPK2 | AATF | – | phosphorylation down-regulates quantity | 25210797 | SIGNOR-278942 | |
| HIPK2 | ZBTB4 | Thr795 | AAERPGGtPTPVIAY | phosphorylation down-regulates activity | 19448668 | SIGNOR-262880 |
| HIPK2 | ZBTB4 | Thr797 | ERPGGTPtPVIAYSK | phosphorylation down-regulates activity | 19448668 | SIGNOR-262881 |
| HIPK2 | ZBTB4 | Thr983 | AAPPAPPtPPPPTLP | phosphorylation down-regulates activity | 19448668 | SIGNOR-262882 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer54 | phosphorylation down-regulates ⊣ | PPM1D | 23871434 | SIGNOR-275480 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer85 | phosphorylation down-regulates ⊣ | PPM1D | 23871434 | SIGNOR-275481 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer54 | phosphorylation down-regulates ⊣ | PPM1D | 27308327 | SIGNOR-278229 |
| HIPK2 | phosphorylation up-regulates → | PPM1D PSer85 | phosphorylation down-regulates ⊣ | PPM1D | 27308327 | SIGNOR-278230 |
| HIPK2 | phosphorylation up-regulates → | HDAC3 PSer374 | phosphorylation down-regulates ⊣ | HDAC3 | 34244427 | SIGNOR-277568 |
| HIPK2 | phosphorylation up-regulates → | TP53 PSer46 | phosphorylation up-regulates → | TP53 | 17210684 | SIGNOR-151930 |
| HIPK2 | phosphorylation up-regulates → | CREB1 PSer257 | phosphorylation up-regulates → | CREB1 | 20573984 | SIGNOR-166338 |
| HIPK2 | phosphorylation up-regulates → | HMGA1 PSer36 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158616 |
| HIPK2 | phosphorylation up-regulates → | HMGA1 PThr53 | phosphorylation down-regulates ⊣ | HMGA1 | 17960875 | SIGNOR-158620 |
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr281 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251269 |
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr304 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251270 |
| HIPK2 | phosphorylation up-regulates → | PAX6 PThr373 | phosphorylation up-regulates → | PAX6 | 16407227 | SIGNOR-251271 |
| HIPK2 | phosphorylation up-regulates → | PML PSer38 | phosphorylation up-regulates → | PML | 19015637 | SIGNOR-182428 |
| HIPK2 | phosphorylation up-regulates → | PML PSer8 | phosphorylation up-regulates → | PML | 19015637 | SIGNOR-182432 |
| HIPK2 | phosphorylation up-regulates → | CDKN1B PSer10 | phosphorylation up-regulates → | CDKN1B | 21715331 | SIGNOR-174617 |
| HIPK2 | phosphorylation up-regulates → | MECP2 PSer80 | phosphorylation up-regulates → | MECP2 | 19820693 | SIGNOR-264549 |
| HIPK2 | phosphorylation up-regulates → | PDX1 PSer268 | phosphorylation down-regulates ⊣ | PDX1 | 20637728 | SIGNOR-255539 |
| HIPK2 | phosphorylation up-regulates → | CTBP1 PSer422 | phosphorylation down-regulates ⊣ | CTBP1 | 15708980 | SIGNOR-134040 |
| HIPK2 | phosphorylation up-regulates → | HIPK2 PSer882 | phosphorylation up-regulates → | HIPK2 | 24145406 | SIGNOR-276600 |
| HIPK2 | phosphorylation up-regulates → | HIPK2 PThr880 | phosphorylation up-regulates → | HIPK2 | 24145406 | SIGNOR-276601 |
| HIPK2 | phosphorylation up-regulates → | ZBTB4 PThr795 | phosphorylation down-regulates ⊣ | ZBTB4 | 19448668 | SIGNOR-262880 |
| HIPK2 | phosphorylation up-regulates → | ZBTB4 PThr797 | phosphorylation down-regulates ⊣ | ZBTB4 | 19448668 | SIGNOR-262881 |
| HIPK2 | phosphorylation up-regulates → | ZBTB4 PThr983 | phosphorylation down-regulates ⊣ | ZBTB4 | 19448668 | SIGNOR-262882 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| HIPK2 | phosphorylation → up-regulates activity | CBX4 | SIGNOR-278484 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275480 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-275481 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-278229 |
| HIPK2 | phosphorylation down-regulates quantity by destabilization | PPM1D | SIGNOR-278230 |
| HIPK2 | phosphorylation → down-regulates activity | HDAC3 | SIGNOR-277568 |
| HIPK2 | phosphorylation → up-regulates | TP53 | SIGNOR-151930 |
| HIPK2 | phosphorylation → down-regulates quantity | BCHE | SIGNOR-279190 |
| HIPK2 | phosphorylation → down-regulates activity | TCF3 | SIGNOR-279193 |
| HIPK2 | phosphorylation → up-regulates | CREB1 | SIGNOR-166338 |
| HIPK2 | phosphorylation down-regulates | HMGA1 | SIGNOR-158616 |
| HIPK2 | phosphorylation down-regulates | HMGA1 | SIGNOR-158620 |
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251269 |
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251270 |
| HIPK2 | phosphorylation → up-regulates activity | PAX6 | SIGNOR-251271 |
| HIPK2 | phosphorylation → up-regulates | PML | SIGNOR-182428 |
| HIPK2 | phosphorylation → up-regulates | PML | SIGNOR-182432 |
| HIPK2 | phosphorylation → up-regulates | CDKN1B | SIGNOR-174617 |
| HIPK2 | phosphorylation → up-regulates activity | MECP2 | SIGNOR-264549 |
| HIPK2 | phosphorylation → unknown | PDX1 | SIGNOR-255539 |
| HIPK2 | phosphorylation → down-regulates activity | MDM2 | SIGNOR-279465 |
| HIPK2 | phosphorylation → down-regulates activity | MEF2C | SIGNOR-279192 |
| HIPK2 | phosphorylation → up-regulates activity | FOXM1 | SIGNOR-278944 |
| HIPK2 | phosphorylation → up-regulates activity | EP300 | SIGNOR-278943 |
| HIPK2 | phosphorylation down-regulates | CTBP1 | SIGNOR-134040 |
| HIPK2 | phosphorylation → down-regulates activity | DAZAP2 | SIGNOR-279335 |
| HIPK2 | phosphorylation → up-regulates activity | CREBBP | SIGNOR-279191 |
| HIPK2 | phosphorylation → up-regulates activity | HIPK2 | SIGNOR-276600 |
| HIPK2 | phosphorylation → up-regulates activity | HIPK2 | SIGNOR-276601 |
| HIPK2 | phosphorylation → down-regulates quantity | AATF | SIGNOR-278942 |
| HIPK2 | phosphorylation → down-regulates activity | ZBTB4 | SIGNOR-262880 |
| HIPK2 | phosphorylation → down-regulates activity | ZBTB4 | SIGNOR-262881 |
| HIPK2 | phosphorylation → down-regulates activity | ZBTB4 | SIGNOR-262882 |