Modifier	Substrate	Residue	Sequence	Mechanism/Effect	PMID	Interaction ID
HIPK2	HIPK2	Thr880	QTIVIPDtPSPTVSV	phosphorylation up-regulates activity	24145406	SIGNOR-276601
PRKAA1	HIPK2	Thr1114	APAALGStGTVAHLV	phosphorylation up-regulates activity	23871434	SIGNOR-276469
SRC	HIPK2	–		phosphorylation up-regulates activity	24196445	SIGNOR-278989
AMPK	HIPK2	Ser121	LMRRSTVsLLDTYQK	phosphorylation down-regulates activity	23871434	SIGNOR-275483
PRKAA2	HIPK2	Thr1116	AALGSTGtVAHLVAS	phosphorylation down-regulates activity	23871434	SIGNOR-275487
AMPK	HIPK2	Thr119	HNLMRRStVSLLDTY	phosphorylation down-regulates activity	23871434	SIGNOR-275482
AMPK	HIPK2	Thr1116	AALGSTGtVAHLVAS	phosphorylation down-regulates activity	23871434	SIGNOR-275484
PRKAA2	HIPK2	Ser121	LMRRSTVsLLDTYQK	phosphorylation down-regulates activity	23871434	SIGNOR-275486
ABL1	HIPK2	Tyr367	TYLQSRYyRAPEIIL	phosphorylation up-regulates activity	25944899	SIGNOR-260936
PRKAA2	HIPK2	Thr119	HNLMRRStVSLLDTY	phosphorylation down-regulates activity	23871434	SIGNOR-275485
HIPK2	HIPK2	Ser882	IVIPDTPsPTVSVIT	phosphorylation up-regulates activity	24145406	SIGNOR-276600
PRKAA1	HIPK2	Ser121	LMRRSTVsLLDTYQK	phosphorylation up-regulates activity	23871434	SIGNOR-276467
PRKAA1	HIPK2	Thr119	HNLMRRStVSLLDTY	phosphorylation up-regulates activity	23871434	SIGNOR-276468

Enzyme	Effect	Phosphosite	Effect	Target	PMID	Interaction ID
HIPK2	phosphorylation up-regulates →	HIPK2 PThr880	phosphorylation up-regulates →	HIPK2	24145406	SIGNOR-276601
PRKAA1	phosphorylation up-regulates →	HIPK2 PThr1114	phosphorylation up-regulates →	HIPK2	23871434	SIGNOR-276469
AMPK	phosphorylation up-regulates →	HIPK2 PSer121	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275483
PRKAA2	phosphorylation up-regulates →	HIPK2 PThr1116	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275487
AMPK	phosphorylation up-regulates →	HIPK2 PThr119	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275482
AMPK	phosphorylation up-regulates →	HIPK2 PThr1116	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275484
PRKAA2	phosphorylation up-regulates →	HIPK2 PSer121	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275486
ABL1	phosphorylation up-regulates →	HIPK2 PTyr367	phosphorylation up-regulates →	HIPK2	25944899	SIGNOR-260936
PRKAA2	phosphorylation up-regulates →	HIPK2 PThr119	phosphorylation down-regulates ⊣	HIPK2	23871434	SIGNOR-275485
HIPK2	phosphorylation up-regulates →	HIPK2 PSer882	phosphorylation up-regulates →	HIPK2	24145406	SIGNOR-276600
PRKAA1	phosphorylation up-regulates →	HIPK2 PSer121	phosphorylation up-regulates →	HIPK2	23871434	SIGNOR-276467
PRKAA1	phosphorylation up-regulates →	HIPK2 PThr119	phosphorylation up-regulates →	HIPK2	23871434	SIGNOR-276468

Regulator	Mechanism/Effect	Target	SIGNOR-ID
HIPK2	phosphorylation → up-regulates activity	HIPK2	SIGNOR-276601
PRKAA1	phosphorylation → up-regulates activity	HIPK2	SIGNOR-276469
SRC	phosphorylation → up-regulates activity	HIPK2	SIGNOR-278989
AMPK	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275483
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275487
AMPK	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275482
AMPK	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275484
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275486
ABL1	phosphorylation → up-regulates activity	HIPK2	SIGNOR-260936
PRKAA2	phosphorylation → down-regulates activity	HIPK2	SIGNOR-275485
HIPK2	phosphorylation → up-regulates activity	HIPK2	SIGNOR-276600
PRKAA1	phosphorylation → up-regulates activity	HIPK2	SIGNOR-276467
PRKAA1	phosphorylation → up-regulates activity	HIPK2	SIGNOR-276468