| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | HIPK2 | Thr1116 | AALGSTGtVAHLVAS | phosphorylation down-regulates activity | 23871434 | SIGNOR-275487 |
| AMPK | HIPK2 | Thr1116 | AALGSTGtVAHLVAS | phosphorylation down-regulates activity | 23871434 | SIGNOR-275484 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PRKAA2 | phosphorylation up-regulates → | HIPK2 PThr1116 | phosphorylation down-regulates ⊣ | HIPK2 | 23871434 | SIGNOR-275487 |
| AMPK | phosphorylation up-regulates → | HIPK2 PThr1116 | phosphorylation down-regulates ⊣ | HIPK2 | 23871434 | SIGNOR-275484 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PRKAA2 | phosphorylation → down-regulates activity | HIPK2 | SIGNOR-275487 |
| AMPK | phosphorylation → down-regulates activity | HIPK2 | SIGNOR-275484 |