| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | TP63 | Ser310 | LYNFMCNsSCVGGMN | phosphorylation down-regulates quantity by destabilization | 30301786 | SIGNOR-277414 |
| RPS6KB1 | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180784 |
| RPS6KB1 | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180771 |
| ATM | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180755 |
| CDK2 | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180759 |
| ABL1 | TP63 | Tyr149 | SVTAPSPyAQPSSTF | phosphorylation up-regulates quantity by stabilization | 19783996 | SIGNOR-260934 |
| CDK2 | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180767 |
| ABL1 | TP63 | Tyr290 | RQSVLVPyEPPQVGT | phosphorylation up-regulates quantity by stabilization | 19783996 | SIGNOR-260933 |
| ABL1 | TP63 | Tyr171 | AIPSNTDyPGPHSFD | phosphorylation up-regulates quantity by stabilization | 19783996 | SIGNOR-260932 |
| ATM | TP63 | Ser560 | LARLGCSsCLDYFTT | phosphorylation down-regulates | 18769144 | SIGNOR-180751 |
| TGFBR1 | TP63 | Ser160 | SSTFDALsPSPAIPS | phosphorylation unknown | 23166821 | SIGNOR-199781 |
| RPS6KB1 | TP63 | Ser560 | LARLGCSsCLDYFTT | phosphorylation down-regulates | 18769144 | SIGNOR-180775 |
| CDK2 | TP63 | Ser560 | LARLGCSsCLDYFTT | phosphorylation down-regulates | 18769144 | SIGNOR-180763 |
| ATM | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180747 |
| MAPK14 | TP63 | Ser301 | S-->T | phosphorylation down-regulates quantity by destabilization | 30301786 | SIGNOR-277414 |
| TGFBR1 | TP63 | Ser68 | FLEQPICsVQPIDLN | phosphorylation unknown | 23166821 | SIGNOR-199785 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| MAPK14 | phosphorylation up-regulates → | TP63 PSer310 | phosphorylation down-regulates ⊣ | TP63 | 30301786 | SIGNOR-277414 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180784 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180771 |
| ATM | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180755 |
| CDK2 | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180759 |
| ABL1 | phosphorylation up-regulates → | TP63 PTyr149 | phosphorylation up-regulates → | TP63 | 19783996 | SIGNOR-260934 |
| CDK2 | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180767 |
| ABL1 | phosphorylation up-regulates → | TP63 PTyr290 | phosphorylation up-regulates → | TP63 | 19783996 | SIGNOR-260933 |
| ABL1 | phosphorylation up-regulates → | TP63 PTyr171 | phosphorylation up-regulates → | TP63 | 19783996 | SIGNOR-260932 |
| ATM | phosphorylation up-regulates → | TP63 PSer560 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180751 |
| TGFBR1 | phosphorylation up-regulates → | TP63 PSer160 | phosphorylation down-regulates ⊣ | TP63 | 23166821 | SIGNOR-199781 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PSer560 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180775 |
| CDK2 | phosphorylation up-regulates → | TP63 PSer560 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180763 |
| ATM | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180747 |
| MAPK14 | phosphorylation up-regulates → | TP63 PSer301 | phosphorylation down-regulates ⊣ | TP63 | 30301786 | SIGNOR-277414 |
| TGFBR1 | phosphorylation up-regulates → | TP63 PSer68 | phosphorylation down-regulates ⊣ | TP63 | 23166821 | SIGNOR-199785 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| MAPK14 | phosphorylation down-regulates quantity by destabilization | TP63 | SIGNOR-277414 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180784 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180771 |
| ATM | phosphorylation down-regulates | TP63 | SIGNOR-180755 |
| CDK2 | phosphorylation down-regulates | TP63 | SIGNOR-180759 |
| ABL1 | phosphorylation → up-regulates quantity by stabilization | TP63 | SIGNOR-260934 |
| CDK2 | phosphorylation down-regulates | TP63 | SIGNOR-180767 |
| ABL1 | phosphorylation → up-regulates quantity by stabilization | TP63 | SIGNOR-260933 |
| ABL1 | phosphorylation → up-regulates quantity by stabilization | TP63 | SIGNOR-260932 |
| ATM | phosphorylation down-regulates | TP63 | SIGNOR-180751 |
| TGFBR1 | phosphorylation → unknown | TP63 | SIGNOR-199781 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180775 |
| CDK2 | phosphorylation down-regulates | TP63 | SIGNOR-180763 |
| ATM | phosphorylation down-regulates | TP63 | SIGNOR-180747 |
| MAPK14 | phosphorylation down-regulates quantity by destabilization | TP63 | SIGNOR-277414 |
| TGFBR1 | phosphorylation → unknown | TP63 | SIGNOR-199785 |
