| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180767 |
| RPS6KB1 | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180784 |
| ATM | TP63 | Thr491 | PQQRNALtPTTIPDG | phosphorylation down-regulates | 18769144 | SIGNOR-180755 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| CDK2 | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180767 |
| RPS6KB1 | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180784 |
| ATM | phosphorylation up-regulates → | TP63 PThr491 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180755 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| CDK2 | phosphorylation down-regulates | TP63 | SIGNOR-180767 |
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180784 |
| ATM | phosphorylation down-regulates | TP63 | SIGNOR-180755 |
