| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180771 |
| CDK2 | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180759 |
| ATM | TP63 | Ser477 | NSMNKLPsVSQLINP | phosphorylation down-regulates | 18769144 | SIGNOR-180747 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| RPS6KB1 | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180771 |
| CDK2 | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180759 |
| ATM | phosphorylation up-regulates → | TP63 PSer477 | phosphorylation down-regulates ⊣ | TP63 | 18769144 | SIGNOR-180747 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| RPS6KB1 | phosphorylation down-regulates | TP63 | SIGNOR-180771 |
| CDK2 | phosphorylation down-regulates | TP63 | SIGNOR-180759 |
| ATM | phosphorylation down-regulates | TP63 | SIGNOR-180747 |
