Entity Details

Name SRMS
ID Q9H3Y6
Role kinase
Enzymatic Domains
SH3 51-112
PROSITE-ProRule
SH2 120-212
PROSITE-ProRule
Protein kinase 230-488
PROSITE-ProRule
View in

Data Summary
PTM Format
SIGNOR Summary
Modifier Substrate Residue Sequence Mechanism/Effect PMID Interaction ID
SRMSMAP2K4Tyr269RDAGCRPyMAPERIDphosphorylation
down-regulates activity		37020040SIGNOR-277903
SRMSMAP2K4Tyr307LATGRFPyPKWNSVFphosphorylation
down-regulates activity		37020040SIGNOR-277902
SRMSFKBP4–phosphorylation
down-regulates activity		34077419SIGNOR-279764
SRMSFKBP5Tyr54PMIGDKVyVHYKGKLphosphorylation
down-regulates quantity by destabilization		34077419SIGNOR-277564
SRMSDOK1–phosphorylation
unknown		23822091SIGNOR-264569
Enzyme Effect Phosphosite Effect Target PMID Interaction ID
SRMSphosphorylation
up-regulates
→
MAP2K4
PTyr269		phosphorylation
down-regulates
⊣		MAP2K437020040SIGNOR-277903
SRMSphosphorylation
up-regulates
→
MAP2K4
PTyr307		phosphorylation
down-regulates
⊣		MAP2K437020040SIGNOR-277902
SRMSphosphorylation
up-regulates
→
FKBP5
PTyr54		phosphorylation
down-regulates
⊣		FKBP534077419SIGNOR-277564
Regulator Mechanism/Effect Target SIGNOR-ID
SRMSphosphorylation
→
down-regulates activity 		MAP2K4SIGNOR-277903
SRMSphosphorylation
→
down-regulates activity 		MAP2K4SIGNOR-277902
SRMSphosphorylation
→
down-regulates activity 		FKBP4SIGNOR-279764
SRMSphosphorylation
img/direct_inhibition.png
down-regulates quantity by destabilization 		FKBP5SIGNOR-277564
SRMSphosphorylation
→
unknown 		DOK1SIGNOR-264569