| Name | WNK1 |
| ID | Q9H4A3 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 221-479 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | OXSR1 | Ser325 | VRRVPGSsGRLHKTE | phosphorylation up-regulates | 17190791 | SIGNOR-151659 |
| WNK1 | OXSR1 | Thr185 | TRNKVRKtFVGTPCW | phosphorylation up-regulates | 17190791 | SIGNOR-151663 |
| WNK1 | SLC12A2 | Thr1023 | QKKQGKNtIDVWWLF | phosphorylation up-regulates activity | 36318922 | SIGNOR-277859 |
| WNK1 | SMAD2 | – | phosphorylation up-regulates quantity | 28236964 | SIGNOR-280164 | |
| WNK1 | SYT2 | Thr199 | ETKVHRKtLNPAFNE | phosphorylation up-regulates activity | 15350218 | SIGNOR-263049 |
| WNK1 | SLC12A5 | – | phosphorylation down-regulates activity | 23300475 | SIGNOR-280163 | |
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 17190791 | SIGNOR-151675 |
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 18270262 | SIGNOR-160850 |
| WNK1 | WNK1 | Ser382 | LKRASFAkSVIGTPE | phosphorylation up-regulates activity | 12374799 | SIGNOR-260826 |
| WNK1 | STK39 | Ser371 | VRRVPGSsGHLHKTE | phosphorylation up-regulates | 16083423 | SIGNOR-253553 |
| WNK1 | STK39 | Thr231 | TRNKVRKtFVGTPCW | phosphorylation up-regulates | 16083423 | SIGNOR-160846 |
| WNK1 | STK39 | Ser371 | VRRVPGSsGHLHKTE | phosphorylation up-regulates | 17190791 | SIGNOR-151667 |
| WNK1 | STK39 | Thr231 | TRNKVRKtFVGTPCW | phosphorylation up-regulates | 17190791 | SIGNOR-151671 |
| WNK1 | STK39 | Ser371 | VRRVPGSsGHLHKTE | phosphorylation up-regulates | 18270262 | SIGNOR-160842 |
| WNK1 | SLC12A6 | Thr1048 | YQEKVHMtWTKDKYM | phosphorylation down-regulates | 19665974 | SIGNOR-187560 |
| WNK1 | SLC12A6 | Thr991 | SAYTYERtLMMEQRS | phosphorylation down-regulates | 19665974 | SIGNOR-187564 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | phosphorylation up-regulates → | OXSR1 PSer325 | phosphorylation up-regulates → | OXSR1 | 17190791 | SIGNOR-151659 |
| WNK1 | phosphorylation up-regulates → | OXSR1 PThr185 | phosphorylation up-regulates → | OXSR1 | 17190791 | SIGNOR-151663 |
| WNK1 | phosphorylation up-regulates → | SLC12A2 PThr1023 | phosphorylation up-regulates → | SLC12A2 | 36318922 | SIGNOR-277859 |
| WNK1 | phosphorylation up-regulates → | SYT2 PThr199 | phosphorylation up-regulates → | SYT2 | 15350218 | SIGNOR-263049 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 17190791 | SIGNOR-151675 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 18270262 | SIGNOR-160850 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 12374799 | SIGNOR-260826 |
| WNK1 | phosphorylation up-regulates → | STK39 PSer371 | phosphorylation up-regulates → | STK39 | 16083423 | SIGNOR-253553 |
| WNK1 | phosphorylation up-regulates → | STK39 PThr231 | phosphorylation up-regulates → | STK39 | 16083423 | SIGNOR-160846 |
| WNK1 | phosphorylation up-regulates → | STK39 PSer371 | phosphorylation up-regulates → | STK39 | 17190791 | SIGNOR-151667 |
| WNK1 | phosphorylation up-regulates → | STK39 PThr231 | phosphorylation up-regulates → | STK39 | 17190791 | SIGNOR-151671 |
| WNK1 | phosphorylation up-regulates → | STK39 PSer371 | phosphorylation up-regulates → | STK39 | 18270262 | SIGNOR-160842 |
| WNK1 | phosphorylation up-regulates → | SLC12A6 PThr1048 | phosphorylation down-regulates ⊣ | SLC12A6 | 19665974 | SIGNOR-187560 |
| WNK1 | phosphorylation up-regulates → | SLC12A6 PThr991 | phosphorylation down-regulates ⊣ | SLC12A6 | 19665974 | SIGNOR-187564 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK1 | phosphorylation → up-regulates | OXSR1 | SIGNOR-151659 |
| WNK1 | phosphorylation → up-regulates | OXSR1 | SIGNOR-151663 |
| WNK1 | phosphorylation → up-regulates activity | SLC12A2 | SIGNOR-277859 |
| WNK1 | phosphorylation → up-regulates quantity | SMAD2 | SIGNOR-280164 |
| WNK1 | phosphorylation → up-regulates activity | SYT2 | SIGNOR-263049 |
| WNK1 | phosphorylation → down-regulates activity | SLC12A5 | SIGNOR-280163 |
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-151675 |
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-160850 |
| WNK1 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260826 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-253553 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-160846 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-151667 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-151671 |
| WNK1 | phosphorylation → up-regulates | STK39 | SIGNOR-160842 |
| WNK1 | phosphorylation down-regulates | SLC12A6 | SIGNOR-187560 |
| WNK1 | phosphorylation down-regulates | SLC12A6 | SIGNOR-187564 |