| Name | WNK1 |
| ID | Q9H4A3 |
| Role | substrate |
| Enzymatic Domains |
Protein kinase 221-479 PROSITE-ProRule |
View in  |
|
| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 18270262 | SIGNOR-160850 |
| AKT1 | WNK1 | Thr60 | EYRRRRHtMDKDSRG | phosphorylation up-regulates | 16081417 | SIGNOR-252481 |
| WNK1 | WNK1 | Ser382 | LKRASFAkSVIGTPE | phosphorylation up-regulates activity | 12374799 | SIGNOR-260826 |
| WNK3 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates activity | 22032326 | SIGNOR-260789 |
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 17190791 | SIGNOR-151675 |
| WNK2 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates activity | 22032326 | SIGNOR-260790 |
| AKT | WNK1 | Thr60 | EYRRRRHtMDKDSRG | phosphorylation up-regulates | 16081417 | SIGNOR-139391 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 18270262 | SIGNOR-160850 |
| AKT1 | phosphorylation up-regulates → | WNK1 PThr60 | phosphorylation up-regulates → | WNK1 | 16081417 | SIGNOR-252481 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 12374799 | SIGNOR-260826 |
| WNK3 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 22032326 | SIGNOR-260789 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 17190791 | SIGNOR-151675 |
| WNK2 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 22032326 | SIGNOR-260790 |
| AKT | phosphorylation up-regulates → | WNK1 PThr60 | phosphorylation up-regulates → | WNK1 | 16081417 | SIGNOR-139391 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-160850 |
| AKT1 | phosphorylation → up-regulates | WNK1 | SIGNOR-252481 |
| WNK1 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260826 |
| WNK3 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260789 |
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-151675 |
| WNK2 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260790 |
| AKT | phosphorylation → up-regulates | WNK1 | SIGNOR-139391 |