| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK3 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates activity | 22032326 | SIGNOR-260789 |
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 17190791 | SIGNOR-151675 |
| WNK2 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates activity | 22032326 | SIGNOR-260790 |
| WNK1 | WNK1 | Ser382 | KRASFAKsVIGTPEF | phosphorylation up-regulates | 18270262 | SIGNOR-160850 |
| WNK1 | WNK1 | Ser382 | LKRASFAkSVIGTPE | phosphorylation up-regulates activity | 12374799 | SIGNOR-260826 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| WNK3 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 22032326 | SIGNOR-260789 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 17190791 | SIGNOR-151675 |
| WNK2 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 22032326 | SIGNOR-260790 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 18270262 | SIGNOR-160850 |
| WNK1 | phosphorylation up-regulates → | WNK1 PSer382 | phosphorylation up-regulates → | WNK1 | 12374799 | SIGNOR-260826 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| WNK3 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260789 |
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-151675 |
| WNK2 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260790 |
| WNK1 | phosphorylation → up-regulates | WNK1 | SIGNOR-160850 |
| WNK1 | phosphorylation → up-regulates activity | WNK1 | SIGNOR-260826 |
