| Name | PLK3 |
| ID | Q9H4B4 |
| Role | kinase |
| Enzymatic Domains |
Protein kinase 62-314 PROSITE-ProRule
POLO box 1 463-541 PROSITE-ProRule
POLO box 2 562-645 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK3 | TP73 | – | phosphorylation down-regulates activity | 19490146 | SIGNOR-279647 | |
| PLK3 | CHEK2 | Ser62 | SSSGTLSsLETVSTQ | phosphorylation up-regulates activity | 16481012 | SIGNOR-276052 |
| PLK3 | CHEK2 | Ser73 | VSTQELYsIPEDQEP | phosphorylation up-regulates activity | 16481012 | SIGNOR-276051 |
| PLK3 | TP53 | Ser20 | PLSQETFsDLWKLLP | phosphorylation up-regulates activity | 11447225 | SIGNOR-109239 |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 17804415 | SIGNOR-157721 |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 17804415 | SIGNOR-157725 |
| PLK3 | JUN | Ser63 | KNSDLLTsPDVGLLK | phosphorylation up-regulates | 18650425 | SIGNOR-179551 |
| PLK3 | JUN | Ser73 | VGLLKLAsPELERLI | phosphorylation up-regulates | 18650425 | SIGNOR-179555 |
| PLK3 | TOP2A | Thr1343 | FSDFDEKtDDEDFVP | phosphorylation up-regulates | 18062778 | SIGNOR-159596 |
| PLK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 20068231 | SIGNOR-163270 |
| PLK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 20068231 | SIGNOR-163274 |
| PLK3 | ATF2 | Thr69 | SVIVADQtPTPTRFL | phosphorylation up-regulates | 21098032 | SIGNOR-170004 |
| PLK3 | ATF2 | Thr71 | IVADQTPtPTRFLKN | phosphorylation up-regulates | 21098032 | SIGNOR-170008 |
| PLK3 | H2AX | – | phosphorylation up-regulates activity | 25202016 | SIGNOR-280073 | |
| PLK3 | CDC25A | Thr80 | RMGSSEStDSGFCLD | phosphorylation down-regulates | 18167338 | SIGNOR-160228 |
| PLK3 | CDC25C | Ser216 | SGLYRSPsMPENLNR | phosphorylation unknown | 10557092 | SIGNOR-249030 |
| PLK3 | CDC25C | Ser191 | EDQAEEIsDELMEFS | phosphorylation up-regulates | 14968113 | SIGNOR-122090 |
| PLK3 | CDC25C | Ser198 | SDELMEFsLKDQEAK | phosphorylation up-regulates | 14968113 | SIGNOR-122094 |
| PLK3 | SNCA | Ser129 | NEAYEMPsEEGYQDY | phosphorylation down-regulates activity | 19889641 | SIGNOR-189053 |
| PLK3 | PTEN | Ser370 | TSVTPDVsDNEPDHY | phosphorylation down-regulates activity | 20940307 | SIGNOR-168469 |
| PLK3 | PTEN | Thr366 | ASSSTSVtPDVSDNE | phosphorylation down-regulates activity | 20940307 | SIGNOR-168473 |
| PLK3 | BCL2L1 | Ser49 | ESEMETPsAINGNPS | phosphorylation up-regulates | 21336504 | SIGNOR-172230 |
| PLK3 | CASP8 | Thr273 | DAGALTTtFEELHFE | phosphorylation up-regulates activity | 27325299 | SIGNOR-272995 |
| PLK3 | SNCB | Ser118 | LMEPEGEsYEDPPQE | phosphorylation down-regulates activity | 19889641 | SIGNOR-189057 |
| PLK3 | HIF1A | Ser576 | DDDFQLRsFDQLSPL | phosphorylation down-regulates | 18519666 | SIGNOR-178739 |
| PLK3 | HIF1A | Ser657 | ETTSATSsPYRDTQS | phosphorylation down-regulates | 18519666 | SIGNOR-178743 |
| PLK3 | VRK1 | Ser342 | DDGKLDLsVVENGGL | phosphorylation up-regulates | 19103756 | SIGNOR-182858 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| PLK3 | phosphorylation up-regulates → | CHEK2 PSer62 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276052 |
| PLK3 | phosphorylation up-regulates → | CHEK2 PSer73 | phosphorylation up-regulates → | CHEK2 | 16481012 | SIGNOR-276051 |
| PLK3 | phosphorylation up-regulates → | TP53 PSer20 | phosphorylation up-regulates → | TP53 | 11447225 | SIGNOR-109239 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157721 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 17804415 | SIGNOR-157725 |
| PLK3 | phosphorylation up-regulates → | JUN PSer63 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179551 |
| PLK3 | phosphorylation up-regulates → | JUN PSer73 | phosphorylation up-regulates → | JUN | 18650425 | SIGNOR-179555 |
| PLK3 | phosphorylation up-regulates → | TOP2A PThr1343 | phosphorylation up-regulates → | TOP2A | 18062778 | SIGNOR-159596 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163270 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 20068231 | SIGNOR-163274 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr69 | phosphorylation up-regulates → | ATF2 | 21098032 | SIGNOR-170004 |
| PLK3 | phosphorylation up-regulates → | ATF2 PThr71 | phosphorylation up-regulates → | ATF2 | 21098032 | SIGNOR-170008 |
| PLK3 | phosphorylation up-regulates → | CDC25A PThr80 | phosphorylation down-regulates ⊣ | CDC25A | 18167338 | SIGNOR-160228 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer216 | phosphorylation down-regulates ⊣ | CDC25C | 10557092 | SIGNOR-249030 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer191 | phosphorylation up-regulates → | CDC25C | 14968113 | SIGNOR-122090 |
| PLK3 | phosphorylation up-regulates → | CDC25C PSer198 | phosphorylation up-regulates → | CDC25C | 14968113 | SIGNOR-122094 |
| PLK3 | phosphorylation up-regulates → | SNCA PSer129 | phosphorylation down-regulates ⊣ | SNCA | 19889641 | SIGNOR-189053 |
| PLK3 | phosphorylation up-regulates → | PTEN PSer370 | phosphorylation down-regulates ⊣ | PTEN | 20940307 | SIGNOR-168469 |
| PLK3 | phosphorylation up-regulates → | PTEN PThr366 | phosphorylation down-regulates ⊣ | PTEN | 20940307 | SIGNOR-168473 |
| PLK3 | phosphorylation up-regulates → | BCL2L1 PSer49 | phosphorylation up-regulates → | BCL2L1 | 21336504 | SIGNOR-172230 |
| PLK3 | phosphorylation up-regulates → | CASP8 PThr273 | phosphorylation up-regulates → | CASP8 | 27325299 | SIGNOR-272995 |
| PLK3 | phosphorylation up-regulates → | SNCB PSer118 | phosphorylation down-regulates ⊣ | SNCB | 19889641 | SIGNOR-189057 |
| PLK3 | phosphorylation up-regulates → | HIF1A PSer576 | phosphorylation down-regulates ⊣ | HIF1A | 18519666 | SIGNOR-178739 |
| PLK3 | phosphorylation up-regulates → | HIF1A PSer657 | phosphorylation down-regulates ⊣ | HIF1A | 18519666 | SIGNOR-178743 |
| PLK3 | phosphorylation up-regulates → | VRK1 PSer342 | phosphorylation up-regulates → | VRK1 | 19103756 | SIGNOR-182858 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| PLK3 | phosphorylation → down-regulates activity | TP73 | SIGNOR-279647 |
| PLK3 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276052 |
| PLK3 | phosphorylation → up-regulates activity | CHEK2 | SIGNOR-276051 |
| PLK3 | phosphorylation → up-regulates activity | TP53 | SIGNOR-109239 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157721 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-157725 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179551 |
| PLK3 | phosphorylation → up-regulates | JUN | SIGNOR-179555 |
| PLK3 | phosphorylation → up-regulates | TOP2A | SIGNOR-159596 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163270 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-163274 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-170004 |
| PLK3 | phosphorylation → up-regulates | ATF2 | SIGNOR-170008 |
| PLK3 | phosphorylation → up-regulates activity | H2AX | SIGNOR-280073 |
| PLK3 | phosphorylation down-regulates | CDC25A | SIGNOR-160228 |
| PLK3 | phosphorylation → unknown | CDC25C | SIGNOR-249030 |
| PLK3 | phosphorylation → up-regulates | CDC25C | SIGNOR-122090 |
| PLK3 | phosphorylation → up-regulates | CDC25C | SIGNOR-122094 |
| PLK3 | phosphorylation → down-regulates activity | SNCA | SIGNOR-189053 |
| PLK3 | phosphorylation → down-regulates activity | PTEN | SIGNOR-168469 |
| PLK3 | phosphorylation → down-regulates activity | PTEN | SIGNOR-168473 |
| PLK3 | phosphorylation → up-regulates | BCL2L1 | SIGNOR-172230 |
| PLK3 | phosphorylation → up-regulates activity | CASP8 | SIGNOR-272995 |
| PLK3 | phosphorylation → down-regulates activity | SNCB | SIGNOR-189057 |
| PLK3 | phosphorylation down-regulates | HIF1A | SIGNOR-178739 |
| PLK3 | phosphorylation down-regulates | HIF1A | SIGNOR-178743 |
| PLK3 | phosphorylation → up-regulates | VRK1 | SIGNOR-182858 |