| Name | DEF6 |
| ID | Q9H4E7 |
| Role | substrate |
| Enzymatic Domains |
PH 216-312 PROSITE-ProRule |
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| Modifier | Substrate | Residue | Sequence | Mechanism/Effect | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | DEF6 | Tyr144 | MVPDEVEyLLKKVLS | phosphorylation up-regulates activity | 18976935 | SIGNOR-253368 |
| LCK | DEF6 | Tyr210 | SMAIHEVyQELIQDV | phosphorylation up-regulates activity | 12923183 | SIGNOR-251372 |
| LCK | DEF6 | Tyr133 | NFLSEDKyPLIMVPD | phosphorylation up-regulates activity | 18976935 | SIGNOR-253367 |
| Enzyme | Effect | Phosphosite | Effect | Target | PMID | Interaction ID |
|---|---|---|---|---|---|---|
| LCK | phosphorylation up-regulates → | DEF6 PTyr144 | phosphorylation up-regulates → | DEF6 | 18976935 | SIGNOR-253368 |
| LCK | phosphorylation up-regulates → | DEF6 PTyr210 | phosphorylation up-regulates → | DEF6 | 12923183 | SIGNOR-251372 |
| LCK | phosphorylation up-regulates → | DEF6 PTyr133 | phosphorylation up-regulates → | DEF6 | 18976935 | SIGNOR-253367 |
| Regulator | Mechanism/Effect | Target | SIGNOR-ID |
|---|---|---|---|
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-253368 |
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-251372 |
| LCK | phosphorylation → up-regulates activity | DEF6 | SIGNOR-253367 |